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10.1007/s13277-015-4555-z http://scihub22266oqcxt.onion/10.1007/s13277-015-4555-z C4990612!4990612!26762412     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26762412&cmd=llinks): Failed to open stream: HTTP request failed! 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Cadherin-12 enhances proliferation in colorectal cancer cells and increases progression by promoting EMT |pdf=|usr=}}{{26762412}} gab.com Text Cadherin-12 enhances proliferation in colorectal cancer cells and increases progression by promoting EMT JO: Tumour Biol http://www.kidney.de/pget.php?&tw=1&pmid=26762412 #FOAvip Cadherin-12 (CDH12) is a subtype of N-cadherin family. In this study, we investigated the expression of CDH12 and the role of CDH12 in prognosis of colorectal cancer (CRC) patients. In addition, we observed the influence of CDH12 on proliferation and progression of CRC cell lines. By using immunohistochemical staining, we analyzed CRC samples and adjacent non-tumor tissues collected from 78 patients who underwent laparoscopic surgery in Shanghai Minimally Invasive Center, China. Statistical analyses were used to analyze relationship between CDH12 and tumor features. Kaplan-Meier method was used to analyze patients? survival. Proliferation ability of CRC cells was tested by CCK-8 assay, and transwell assays were performed to detect migration and invasion ability. Western blot assay was performed to investigate epithelial-mesenchymal transition (EMT) variants. We found that expression of CDH12 in tumor tissue was higher than in adjacent normal tissue. High expression of CDH12 was associated with tumor invasion depth and predicts poor prognosis of CRC patients. Ectopic/repressing expression of CDH12 increased/decreased the proliferation and migration ability of CRC cells. CDH12 is able to increase cancer cell migration and invasion via promoting EMT by targeting transcriptional factor Snail. These findings may conclude that CDH12 may act as a predictor in CRC patients? prognosis and an oncogene in CRC cell proliferation and migration. CDH12 may influence CRC cell progression through promoting EMT by targeting Snail. In addition, CDH12 is promoted by MCP1 through induction of MCPIP.Electronic supplementary material: The online version of this article (doi:10.1007/s13277-015-4555-z) contains supplementary material, which is available to authorized users. Twit Text FOAVip Cadherin-12 enhances proliferation in colorectal cancer cells and increases progression by promoting EMT ????Tumour Biol http://www.kidney.de/pget.php?&tw=1&pmid=26762412 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26762412 #FOAvip English Wikipedia <ref>{{Cite pmid|26762412}}</ref> Cadherin-12 enhances proliferation in colorectal cancer cells and increases progression by promoting EMT #MMPMID26762412 Ma J; Zhao J; Lu J; Wang P; Feng H; Zong Y; Ou B; Zheng M; Lu A Tumour Biol 2016[Jul]; 37 (7): 9077-88 PMID26762412show ga Cadherin-12 (CDH12) is a subtype of N-cadherin family. In this study, we investigated the expression of CDH12 and the role of CDH12 in prognosis of colorectal cancer (CRC) patients. In addition, we observed the influence of CDH12 on proliferation and progression of CRC cell lines. By using immunohistochemical staining, we analyzed CRC samples and adjacent non-tumor tissues collected from 78 patients who underwent laparoscopic surgery in Shanghai Minimally Invasive Center, China. Statistical analyses were used to analyze relationship between CDH12 and tumor features. Kaplan-Meier method was used to analyze patients? survival. Proliferation ability of CRC cells was tested by CCK-8 assay, and transwell assays were performed to detect migration and invasion ability. Western blot assay was performed to investigate epithelial-mesenchymal transition (EMT) variants. We found that expression of CDH12 in tumor tissue was higher than in adjacent normal tissue. High expression of CDH12 was associated with tumor invasion depth and predicts poor prognosis of CRC patients. Ectopic/repressing expression of CDH12 increased/decreased the proliferation and migration ability of CRC cells. CDH12 is able to increase cancer cell migration and invasion via promoting EMT by targeting transcriptional factor Snail. These findings may conclude that CDH12 may act as a predictor in CRC patients? prognosis and an oncogene in CRC cell proliferation and migration. CDH12 may influence CRC cell progression through promoting EMT by targeting Snail. In addition, CDH12 is promoted by MCP1 through induction of MCPIP.Electronic supplementary material: The online version of this article (doi:10.1007/s13277-015-4555-z) contains supplementary material, which is available to authorized users. äCadherin-12 enhances proliferation in colorectal cancer cells and incr(epmc).pdf DeepDyve Pubget Overpricing