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10.1007/s12265-016-9705-1 http://scihub22266oqcxt.onion/10.1007/s12265-016-9705-1 C4990609!4990609 !27383837     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27383837 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cardiovasc+Transl+Res 2016 ; 9 (4 ): 291-301 Nephropedia Template TP {{tp|p=27383837 |t=2016. Circulating Extracellular Vesicles Contain miRNAs and are Released as Early Biomarkers for Cardiac Injury |pdf=|usr=}}{{27383837 }} gab.com Text Circulating Extracellular Vesicles Contain miRNAs and are Released as Early Biomarkers for Cardiac Injury JO: J Cardiovasc Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=27383837 #FOAvip Plasma-circulating microRNAs have been implicated as novel early biomarkers for myocardial infarction (MI) due to their high specificity for cardiac injury. For swift clinical translation of this potential biomarker, it is important to understand their temporal and spatial characteristics upon MI. Therefore, we studied the temporal release, potential source, and transportation of circulating miRNAs in different models of ischemia reperfusion (I/R) injury. We demonstrated that extracellular vesicles are released from the ischemic myocardium upon I/R injury. Moreover, we provided evidence that cardiac and muscle-specific miRNAs are transported by extracellular vesicles and are rapidly detectable in plasma. Since these vesicles are enriched for the released miRNAs and their detection precedes traditional damage markers, they hold great potential as specific early biomarkers for MI. Twit Text FOAVip Circulating Extracellular Vesicles Contain miRNAs and are Released as Early Biomarkers for Cardiac Injury ????J Cardiovasc Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=27383837 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27383837 #FOAvip English Wikipedia <ref>{{Cite pmid|27383837 }}</ref> Circulating Extracellular Vesicles Contain miRNAs and are Released as Early Biomarkers for Cardiac Injury #MMPMID27383837 Deddens JC ; Vrijsen KR ; Colijn JM ; Oerlemans MI ; Metz CH ; van der Vlist EJ ; Nolte-'t Hoen EN ; den Ouden K ; Jansen Of Lorkeers SJ ; van der Spoel TI ; Koudstaal S ; Arkesteijn GJ ; Wauben MH ; van Laake LW ; Doevendans PA ; Chamuleau SA ; Sluijter JP J Cardiovasc Transl Res 2016[Aug]; 9 (4 ): 291-301 PMID27383837 show ga Plasma-circulating microRNAs have been implicated as novel early biomarkers for myocardial infarction (MI) due to their high specificity for cardiac injury. For swift clinical translation of this potential biomarker, it is important to understand their temporal and spatial characteristics upon MI. Therefore, we studied the temporal release, potential source, and transportation of circulating miRNAs in different models of ischemia reperfusion (I/R) injury. We demonstrated that extracellular vesicles are released from the ischemic myocardium upon I/R injury. Moreover, we provided evidence that cardiac and muscle-specific miRNAs are transported by extracellular vesicles and are rapidly detectable in plasma. Since these vesicles are enriched for the released miRNAs and their detection precedes traditional damage markers, they hold great potential as specific early biomarkers for MI. |Animals [MESH] |Disease Models, Animal [MESH] |Extracellular Vesicles/*metabolism [MESH] |Female [MESH] |Genetic Markers [MESH] |Isolated Heart Preparation [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |MicroRNAs/blood/*genetics [MESH] |Myocardial Infarction/blood/diagnosis/*genetics [MESH] |Myocardial Reperfusion Injury/blood/diagnosis/*genetics [MESH] |Sus scrofa [MESH]Circulating Extracellular Vesicles Contain miRNAs and are Released as (epmc).pdf DeepDyve Pubget Overpricing