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2015 ; 41
(9
): 993-1005
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Optical Coherence Tomography Imaging of Normal, Chronologically Aged, Photoaged
and Photodamaged Skin: A Systematic Review
#MMPMID26322560
Mamalis A
; Ho D
; Jagdeo J
Dermatol Surg
2015[Sep]; 41
(9
): 993-1005
PMID26322560
show ga
BACKGROUND: Optical coherence tomography (OCT) is capable of providing a
noninvasive real-time cross-sectional image of the skin through light-based
interferometry, a method sometimes described as "light-based ultrasound." One key
application of OCT in dermatology is the visualization of dermal collagen during
chronological aging, photoaging, or photodamage. These skin conditions are
typically managed by the practitioner's subjective assessment of severity and
response to therapy. OBJECTIVE: The purpose of this review is to present
available evidence on the ability of OCT to image normal, chronologically aged,
photoaged and photodamaged skin in human subjects. METHODS AND MATERIALS: The
authors have searched Medline, PubMed, EMBASE, Web of Science, Google Scholar,
and Cochrane Library databases for published literature on the imaging of skin
collagen by OCT using the following search terms: "optical coherence tomography,"
"OCT," "skin," "collagen," "photoaging," "wrinkles," and "photodamage." RESULTS:
The search resulted in 23 articles investigating OCT-based skin collagen imaging,
which met their search criteria. CONCLUSION: The authors anticipate tremendous
growth in the field of OCT-based skin imaging that will parallel the development
ultrasound technology has experienced over the past 30 years. They foresee that
the use of OCT imaging to evaluate skin aging will not only help identify
pathological changes earlier, but will also assist in the evaluation of the
response to therapy longitudinally without biopsy.