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10.1080/15384047.2016.1167291

http://scihub22266oqcxt.onion/10.1080/15384047.2016.1167291
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C4990393!4990393!27105109
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suck abstract from ncbi


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pmid27105109      Cancer+Biol+Ther 2016 ; 17 (6): 579-91
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  • Role of EZH2 histone methyltrasferase in melanoma progression and metastasis #MMPMID27105109
  • Mahmoud F; Shields B; Makhoul I; Hutchins LF; Shalin SC; Tackett AJ
  • Cancer Biol Ther 2016[Jun]; 17 (6): 579-91 PMID27105109show ga
  • There is accumulating evidence that the histone methyltransferase enhancer of zeste homolog 2 (EZH2), the main component of the polycomb-repressive complex 2 (PRC2), is involved in melanoma progression and metastasis. Novel drugs that target and reverse such epigenetic changes may find a way into the management of patients with advanced melanoma. We provide a comprehensive up-to-date review of the role and biology of EZH2 on gene transcription, senescence/apoptosis, melanoma microenvironment, melanocyte stem cells, the immune system, and micro RNA. Furthermore, we discuss EZH2 inhibitors as potential anti-cancer therapy.
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