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10.3332/ecancer.2016.662 http://scihub22266oqcxt.onion/10.3332/ecancer.2016.662 C4990058!4990058!27594907     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ecancermedicalscience 2016 ; 10 (ä): ä Nephropedia Template TP {{tp|p=27594907|t=2016. Complications from carcinoid syndrome: review of the current evidence |pdf=|usr=}}{{27594907}} gab.com Text Complications from carcinoid syndrome: review of the current evidence JO: Ecancermedicalscience http://www.kidney.de/pget.php?&tw=1&pmid=27594907 #FOAvip Patients with well-differentiated neuroendocrine tumours may develop carcinoid syndrome (CS), which is characterised by flushing, abdominal cramps, diarrhoea, and bronchospasms. In this scenario, long-term secretion of vasoactive substances?serotonin, tachynins, and others, may induce fibrogenic responses in local or distant tissues, leading to complications such as carcinoid heart disease (CHD), mesenteric and/or retroperitoneal fibrosis. Rare cases of lung/pleural fibrosis and scleroderma have also been described. Despite it not being well described yet, current evidence suggests the pathogenesis of such fibrogenic complications relies on signalling through 5-HT2B and TGF-?1. Medical management is still very limited and lacks prospective and randomised studies for definitive recommendations. Surgical procedures remain the best definitive treatment option for CHD and abdominal fibrosis. Recently, cognitive impairment has also been described as a potential consequence of CS. This review critically discusses the literature concerning the epidemiology, pathogenesis, clinical features, diagnosis, and treatment options for CS-related long-term complications. Twit Text FOAVip Complications from carcinoid syndrome: review of the current evidence ????Ecancermedicalscience http://www.kidney.de/pget.php?&tw=1&pmid=27594907 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27594907 #FOAvip English Wikipedia <ref>{{Cite pmid|27594907}}</ref> Complications from carcinoid syndrome: review of the current evidence #MMPMID27594907 Mota JM; Sousa LG; Riechelmann RP Ecancermedicalscience 2016[]; 10 (ä): ä PMID27594907show ga Patients with well-differentiated neuroendocrine tumours may develop carcinoid syndrome (CS), which is characterised by flushing, abdominal cramps, diarrhoea, and bronchospasms. In this scenario, long-term secretion of vasoactive substances?serotonin, tachynins, and others, may induce fibrogenic responses in local or distant tissues, leading to complications such as carcinoid heart disease (CHD), mesenteric and/or retroperitoneal fibrosis. Rare cases of lung/pleural fibrosis and scleroderma have also been described. Despite it not being well described yet, current evidence suggests the pathogenesis of such fibrogenic complications relies on signalling through 5-HT2B and TGF-?1. Medical management is still very limited and lacks prospective and randomised studies for definitive recommendations. Surgical procedures remain the best definitive treatment option for CHD and abdominal fibrosis. Recently, cognitive impairment has also been described as a potential consequence of CS. This review critically discusses the literature concerning the epidemiology, pathogenesis, clinical features, diagnosis, and treatment options for CS-related long-term complications. äComplications from carcinoid syndrome: review of the current evidence (epmc).pdf DeepDyve Pubget Overpricing