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10.4103/0973-029X.185898 http://scihub22266oqcxt.onion/10.4103/0973-029X.185898 C4989548!4989548 !27601810     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27601810 &cmd=llinks): Failed to open stream: HTTP request failed! 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Immunohistochemical evaluation of myofibroblasts in odontogenic cysts and tumors: A comparative study |pdf=|usr=}}{{27601810 }} gab.com Text Immunohistochemical evaluation of myofibroblasts in odontogenic cysts and tumors: A comparative study JO: J Oral Maxillofac Pathol http://www.kidney.de/pget.php?&tw=1&pmid=27601810 #FOAvip CONTEXT: Myofibroblasts are fibroblasts with smooth muscle-like features characterized by the presence of a contractile apparatus and found in the connective tissue stroma of normal tissues such as blood vessels and lymph nodes. They are now thought to play a role in the synthesis and reorganization of extracellular matrix, which could contribute to the aggressive biologic behavior of the lesions. AIMS: To compare the mean number of stromal myofibroblasts in dentigerous cysts (DCs), keratocystic odontogenic tumor (KCOT) and ameloblastoma; and to derive a correlation between the stromal myofibroblasts and the known biologic behavior of the lesions. SETTINGS AND DESIGN: A cross-sectional immunohistochemical analysis of cases of DC, KCOT and ameloblastoma. MATERIALS AND METHODS: Twenty paraffin-embedded tissue blocks each of DC, KCOT and multicystic ameloblastoma were selected for the study and diagnosis confirmed through hematoxylin and eosin staining. Tissue sections were analyzed for the number of myofibroblasts using alpha smooth muscle actin (?-SMA) immunostaining. STATISTICAL ANALYSIS: Differences in the mean number of ?-SMA positive cells in each group were analyzed using one-way ANOVA test. Intergroup comparisons of mean values of ?-SMA positive cells were performed using Mann-Whitney U-test. RESULTS: Ameloblastoma showed the highest number of myofibroblasts, whereas DC showed the lowest. Among the groups, there were significant differences between the myofibroblast counts among DC and KCOT and between DC and ameloblastoma, whereas the difference in counts was not statistically significant between KCOT and ameloblastoma. A positive correlation was observed between the myofibroblast count and the known biologic behavior of the lesions. CONCLUSION: Myofibroblasts may act in close association with the epithelial cells to bring about changes in stromal microenvironment, favorable to the growth and progression of the lesion. They may be of great value in predicting the biologic behavior and growth potential of such lesions. Twit Text FOAVip Immunohistochemical evaluation of myofibroblasts in odontogenic cysts and tumors: A comparative study ????J Oral Maxillofac Pathol http://www.kidney.de/pget.php?&tw=1&pmid=27601810 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27601810 #FOAvip English Wikipedia <ref>{{Cite pmid|27601810 }}</ref> Immunohistochemical evaluation of myofibroblasts in odontogenic cysts and tumors: A comparative study #MMPMID27601810 Syamala D ; Suresh R ; Janardhanan M ; Savithri V ; Anand PP ; Jose A J Oral Maxillofac Pathol 2016[May]; 20 (2 ): 208-13 PMID27601810 show ga CONTEXT: Myofibroblasts are fibroblasts with smooth muscle-like features characterized by the presence of a contractile apparatus and found in the connective tissue stroma of normal tissues such as blood vessels and lymph nodes. They are now thought to play a role in the synthesis and reorganization of extracellular matrix, which could contribute to the aggressive biologic behavior of the lesions. AIMS: To compare the mean number of stromal myofibroblasts in dentigerous cysts (DCs), keratocystic odontogenic tumor (KCOT) and ameloblastoma; and to derive a correlation between the stromal myofibroblasts and the known biologic behavior of the lesions. SETTINGS AND DESIGN: A cross-sectional immunohistochemical analysis of cases of DC, KCOT and ameloblastoma. MATERIALS AND METHODS: Twenty paraffin-embedded tissue blocks each of DC, KCOT and multicystic ameloblastoma were selected for the study and diagnosis confirmed through hematoxylin and eosin staining. Tissue sections were analyzed for the number of myofibroblasts using alpha smooth muscle actin (?-SMA) immunostaining. STATISTICAL ANALYSIS: Differences in the mean number of ?-SMA positive cells in each group were analyzed using one-way ANOVA test. Intergroup comparisons of mean values of ?-SMA positive cells were performed using Mann-Whitney U-test. RESULTS: Ameloblastoma showed the highest number of myofibroblasts, whereas DC showed the lowest. Among the groups, there were significant differences between the myofibroblast counts among DC and KCOT and between DC and ameloblastoma, whereas the difference in counts was not statistically significant between KCOT and ameloblastoma. A positive correlation was observed between the myofibroblast count and the known biologic behavior of the lesions. CONCLUSION: Myofibroblasts may act in close association with the epithelial cells to bring about changes in stromal microenvironment, favorable to the growth and progression of the lesion. They may be of great value in predicting the biologic behavior and growth potential of such lesions. äImmunohistochemical evaluation of myofibroblasts in odontogenic cysts (epmc).pdf DeepDyve Pubget Overpricing