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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Hypertens+Rep
2016 ; 18
(8
): 66
Nephropedia Template TP
gab.com Text
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English Wikipedia
Relationship Between Antihypertensive Medications and Cognitive Impairment: Part
II Review of Physiology and Animal Studies
#MMPMID27492369
Peters R
; Schuchman M
; Peters J
; Carlson MC
; Yasar S
Curr Hypertens Rep
2016[Aug]; 18
(8
): 66
PMID27492369
show ga
PURPOSE OF REVIEW: There is an established association between hypertension and
increased risk of poor cognitive performance and dementia including Alzheimer's
disease; however, associations between antihypertensive medications (AHM) and
dementia risk are less clear. An increased interest in AHM has resulted in
expanding publications; however, none of the recent reviews provide comprehensive
review. Our extensive review includes 24 mechanistic animal and human studies
published over the last 5 years assessing relationship between AHM and cognitive
function. RECENT FINDINGS: All classes of AHM showed similar result patterns in
animal studies. The mechanism by which AHM exert their effect was extensively
studied by evaluating well-established pathways of AD disease process, including
amyloid beta (A?), vascular, oxidative stress and inflammation pathways, but only
few studies evaluated the blood pressure lowering effect on the AD disease
process. Methodological limitations of the studies prevent comprehensive
conclusions prior to further work evaluating AHM in animals and larger human
observational studies, and selecting those with promising results for future
RCTs.
|*Disease Models, Animal
[MESH]
|Alzheimer Disease/physiopathology/prevention & control
[MESH]
|Amyloid beta-Peptides/physiology
[MESH]
|Animals
[MESH]
|Antihypertensive Agents/*therapeutic use
[MESH]
|Cognition/drug effects/physiology
[MESH]
|Cognitive Dysfunction/*physiopathology/*prevention & control
[MESH]
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