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10.1038/npp.2016.57 http://scihub22266oqcxt.onion/10.1038/npp.2016.57 C4987852!4987852 !27091381     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27091381 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Neuropsychopharmacology 2016 ; 41 (10 ): 2530-40 Nephropedia Template TP {{tp|p=27091381 |t=2016. Altered Stress-Induced Regulation of Genes in Monocytes in Adults with a History of Childhood Adversity |pdf=|usr=}}{{27091381 }} gab.com Text Altered Stress-Induced Regulation of Genes in Monocytes in Adults with a History of Childhood Adversity JO: Neuropsychopharmacology http://www.kidney.de/pget.php?&tw=1&pmid=27091381 #FOAvip Exposure to serious or traumatic events early in life can lead to persistent alterations in physiological stress response systems, including enhanced cross talk between the neuroendocrine and immune system. These programming effects may be mechanistically involved in mediating the effects of adverse childhood experience on disease risk in adulthood. We investigated hormonal and genome-wide mRNA expression responses in monocytes to acute stress exposure, in a sample of healthy adults (n=30) with a history of early childhood adversity, and a control group (n=30) without trauma experience. The early adversity group showed altered hypothalamus-pituitary-adrenal axis responses to stress, evidenced by lower ACTH and cortisol responses. Analyses of gene expression patterns showed that stress-responsive transcripts were enriched for genes involved in cytokine activity, cytokine-cytokine receptor interaction, chemokine activity, and G-protein coupled receptor binding. Differences between groups in stress-induced regulation of gene transcription were observed for genes involved in steroid binding, hormone activity, and G-protein coupled receptor binding. Transcription factor binding motif analysis showed an increased activity of pro-inflammatory upstream signaling in the early adversity group. We also identified transcripts that were differentially correlated with stress-induced cortisol increases between the groups, enriched for genes involved in cytokine-cytokine receptor interaction and glutamate receptor signaling. We suggest that childhood adversity leads to persistent alterations in transcriptional control of stress-responsive pathways, which-when chronically or repeatedly activated-might predispose individuals to stress-related psychopathology. Twit Text FOAVip Altered Stress-Induced Regulation of Genes in Monocytes in Adults with a History of Childhood Adversity ????Neuropsychopharmacology http://www.kidney.de/pget.php?&tw=1&pmid=27091381 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27091381 #FOAvip English Wikipedia <ref>{{Cite pmid|27091381 }}</ref> Altered Stress-Induced Regulation of Genes in Monocytes in Adults with a History of Childhood Adversity #MMPMID27091381 Schwaiger M ; Grinberg M ; Moser D ; Zang JC ; Heinrichs M ; Hengstler JG ; Rahnenführer J ; Cole S ; Kumsta R Neuropsychopharmacology 2016[Sep]; 41 (10 ): 2530-40 PMID27091381 show ga Exposure to serious or traumatic events early in life can lead to persistent alterations in physiological stress response systems, including enhanced cross talk between the neuroendocrine and immune system. These programming effects may be mechanistically involved in mediating the effects of adverse childhood experience on disease risk in adulthood. We investigated hormonal and genome-wide mRNA expression responses in monocytes to acute stress exposure, in a sample of healthy adults (n=30) with a history of early childhood adversity, and a control group (n=30) without trauma experience. The early adversity group showed altered hypothalamus-pituitary-adrenal axis responses to stress, evidenced by lower ACTH and cortisol responses. Analyses of gene expression patterns showed that stress-responsive transcripts were enriched for genes involved in cytokine activity, cytokine-cytokine receptor interaction, chemokine activity, and G-protein coupled receptor binding. Differences between groups in stress-induced regulation of gene transcription were observed for genes involved in steroid binding, hormone activity, and G-protein coupled receptor binding. Transcription factor binding motif analysis showed an increased activity of pro-inflammatory upstream signaling in the early adversity group. We also identified transcripts that were differentially correlated with stress-induced cortisol increases between the groups, enriched for genes involved in cytokine-cytokine receptor interaction and glutamate receptor signaling. We suggest that childhood adversity leads to persistent alterations in transcriptional control of stress-responsive pathways, which-when chronically or repeatedly activated-might predispose individuals to stress-related psychopathology. |Adrenocorticotropic Hormone/blood [MESH] |Child [MESH] |Child Abuse/psychology [MESH] |Cytokines/genetics/*metabolism [MESH] |Female [MESH] |Gene Expression [MESH] |Gene Expression Regulation/physiology [MESH] |Humans [MESH] |Hydrocortisone/blood [MESH] |Male [MESH] |Middle Aged [MESH] |Monocytes/*metabolism [MESH] |RNA, Messenger/metabolism [MESH] |Receptors, Cytokine/genetics/metabolism [MESH] |Statistics, Nonparametric [MESH] |Stress, Psychological/blood/*pathology/*physiopathology [MESH]Altered Stress-Induced Regulation of Genes in Monocytes in Adults with(epmc).pdf DeepDyve Pubget Overpricing