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10.1038/cdd.2016.4 http://scihub22266oqcxt.onion/10.1038/cdd.2016.4 C4987737!4987737 !26943324     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26943324 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Differ 2016 ; 23 (6 ): 1016-25 Nephropedia Template TP {{tp|p=26943324 |t=2016. A blast without power - cell death induced by the tuberculosis-necrotizing toxin fails to elicit adequate immune responses |pdf=|usr=}}{{26943324 }} gab.com Text A blast without power - cell death induced by the tuberculosis-necrotizing toxin fails to elicit adequate immune responses JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=26943324 #FOAvip In this study, we deploy a doxycycline-dependent suicide switch integrated in a tumor challenge model. With this experimental setup, we characterized the immunological consequences of cells dying by four distinct cell death stimuli in vivo. We observed that apoptotic cell death induced by expression of the truncated form of BH3 interacting-domain death agonist (tBid) and a constitutively active form of caspase 3 (revC3), respectively, showed higher immunogenicity than cell death induced by expression of the tuberculosis-necrotizing toxin (TNT). Our data indicate that the early release of ATP induces the silent clearance of dying cells, whereas the simultaneous presence of 'find me' signals and danger-associated molecular patterns (DAMPs) promotes inflammatory reactions and increased immunogenicity. This proposed model is supported by findings showing that the production and release of high concentrations of IL-27 by bone-marrow-derived macrophages (BMDM) is limited to BMDM exposed to those forms of death that simultaneously released ATP and the DAMPs heat-shock protein 90 (HSP90) and high-mobility group box-1 protein (HMGB1). These results demonstrate that the tissue microenvironment generated by dying cells may determine the subsequent immune response. Twit Text FOAVip A blast without power - cell death induced by the tuberculosis-necrotizing toxin fails to elicit adequate immune responses ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=26943324 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26943324 #FOAvip English Wikipedia <ref>{{Cite pmid|26943324 }}</ref> A blast without power - cell death induced by the tuberculosis-necrotizing toxin fails to elicit adequate immune responses #MMPMID26943324 Maueröder C ; Chaurio RA ; Dumych T ; Podolska M ; Lootsik MD ; Culemann S ; Friedrich RP ; Bilyy R ; Alexiou C ; Schett G ; Berens C ; Herrmann M ; Munoz LE Cell Death Differ 2016[Jun]; 23 (6 ): 1016-25 PMID26943324 show ga In this study, we deploy a doxycycline-dependent suicide switch integrated in a tumor challenge model. With this experimental setup, we characterized the immunological consequences of cells dying by four distinct cell death stimuli in vivo. We observed that apoptotic cell death induced by expression of the truncated form of BH3 interacting-domain death agonist (tBid) and a constitutively active form of caspase 3 (revC3), respectively, showed higher immunogenicity than cell death induced by expression of the tuberculosis-necrotizing toxin (TNT). Our data indicate that the early release of ATP induces the silent clearance of dying cells, whereas the simultaneous presence of 'find me' signals and danger-associated molecular patterns (DAMPs) promotes inflammatory reactions and increased immunogenicity. This proposed model is supported by findings showing that the production and release of high concentrations of IL-27 by bone-marrow-derived macrophages (BMDM) is limited to BMDM exposed to those forms of death that simultaneously released ATP and the DAMPs heat-shock protein 90 (HSP90) and high-mobility group box-1 protein (HMGB1). These results demonstrate that the tissue microenvironment generated by dying cells may determine the subsequent immune response. |Alarmins/metabolism [MESH] |Animals [MESH] |Apoptosis/*drug effects/radiation effects [MESH] |BH3 Interacting Domain Death Agonist Protein/genetics/metabolism [MESH] |Caspase 3/metabolism [MESH] |Cell Line, Tumor [MESH] |Cytokines/analysis [MESH] |Doxycycline/pharmacology [MESH] |HMGB1 Protein/analysis [MESH] |Interleukin-27/analysis [MESH] |Macrophages/cytology/immunology/metabolism [MESH] |Melanoma, Experimental/metabolism/pathology [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Inbred C57BL [MESH] |Reactive Oxygen Species/metabolism [MESH] |Spleen/cytology/transplantation [MESH] |Toxins, Biological/genetics/*metabolism [MESH] |Transplantation, Homologous [MESH]A blast without power - cell death induced by the tuberculosis-necroti(epmc).pdf DeepDyve Pubget Overpricing