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10.11909/j.issn.1671-5411.2016.06.001 http://scihub22266oqcxt.onion/10.11909/j.issn.1671-5411.2016.06.001 C4987417!4987417!27582763     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Geriatr+Cardiol 2016 ; 13 (6): 489-98 Nephropedia Template TP {{tp|p=27582763|t=2016. Aortic stenosis: insights on pathogenesis and clinical implications |pdf=|usr=}}{{27582763}} gab.com Text Aortic stenosis: insights on pathogenesis and clinical implications JO: J Geriatr Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=27582763 #FOAvip Aortic stenosis (AS) is a common valvular heart disease in the Western populations, with an estimated overall prevalence of 3% in adults over 75 years. To understand its patho-biological processes represents a priority. In elderly patients, AS usually involves trileaflet valves and is referred to as degenerative calcific processes. Scientific evidence suggests the involvement of an active ?atherosclerosis-like? pathogenesis in the initiation phase of degenerative AS. To the contrary, the progression could be driven by different forces (such as mechanical stress, genetic factors and interaction between inflammation and calcification). The improved understanding presents potentially new therapeutic targets for preventing and inhibiting the development and progression of the disease. Furthermore, in clinical practice the management of AS patients implies the evaluation of generalized atherosclerotic manifestations (i.e., in the coronary and carotid arteries) even for prognostic reasons. In counselling elderly patients, the risk stratification should address individual frailty beyond the generic risk scores. In these regard, the co-morbidities, and in particular those linked to the global atherosclerotic burden, should be carefully investigated in order to define the risk/benefit ratio for invasive treatment strategies. We present a detailed overview of insights in pathogenesis of AS with possible practical implications. Twit Text FOAVip Aortic stenosis: insights on pathogenesis and clinical implications ????J Geriatr Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=27582763 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27582763 #FOAvip English Wikipedia <ref>{{Cite pmid|27582763}}</ref> Aortic stenosis: insights on pathogenesis and clinical implications #MMPMID27582763 Carità P; Coppola G; Novo G; Caccamo G; Guglielmo M; Balasus F; Novo S; Castrovinci S; Moscarelli M; Fattouch K; Corrado E J Geriatr Cardiol 2016[Sep]; 13 (6): 489-98 PMID27582763show ga Aortic stenosis (AS) is a common valvular heart disease in the Western populations, with an estimated overall prevalence of 3% in adults over 75 years. To understand its patho-biological processes represents a priority. In elderly patients, AS usually involves trileaflet valves and is referred to as degenerative calcific processes. Scientific evidence suggests the involvement of an active ?atherosclerosis-like? pathogenesis in the initiation phase of degenerative AS. To the contrary, the progression could be driven by different forces (such as mechanical stress, genetic factors and interaction between inflammation and calcification). The improved understanding presents potentially new therapeutic targets for preventing and inhibiting the development and progression of the disease. Furthermore, in clinical practice the management of AS patients implies the evaluation of generalized atherosclerotic manifestations (i.e., in the coronary and carotid arteries) even for prognostic reasons. In counselling elderly patients, the risk stratification should address individual frailty beyond the generic risk scores. In these regard, the co-morbidities, and in particular those linked to the global atherosclerotic burden, should be carefully investigated in order to define the risk/benefit ratio for invasive treatment strategies. We present a detailed overview of insights in pathogenesis of AS with possible practical implications. äAortic stenosis: insights on pathogenesis and clinical implications (epmc).pdf DeepDyve Pubget Overpricing