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2016 ; 8
(3
): 262-7
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The Effectiveness of Oral Corticosteroids for Management of Lumbar Radiating
Pain: Randomized, Controlled Trial Study
#MMPMID27583108
Ko S
; Kim S
; Kim J
; Oh T
Clin Orthop Surg
2016[Sep]; 8
(3
): 262-7
PMID27583108
show ga
BACKGROUND: Although both pregabalin and gabapentin are known to be useful for
treating lumbar radiating pain and reducing the incidence of surgery, the oral
corticosteroids sometimes offer a dramatic effect on severe radiating pain
despite the lack of scientific evidence. METHODS: A total of 54 patients were
enrolled among 703 patients who complained of lumbar radiating pain. Twenty
patients who received an oral corticosteroid was classified as group A and 20
patients who received the control drugs (pregabalin or gabapentin) as group B.
Oswestry Disability Index (ODI), Revised Roland Morris disability questionnaire
(RMDQ), Short Form 36 (SF-36) questionnaire, lumbar radiating pain, objective
patient satisfaction, and objective improvement of patients or physicians were
assessed at 2, 6, and 12 weeks after medication. RESULTS: No difference in the
sex ratio and age was observed between the groups (p = 0.70 and p = 0.13,
respectively). Group A showed greater improvement in radiating pain after 2, 6,
and 12 weeks than group B (p < 0.001, p = 0.001, and p < 0.001, respectively). No
differences were observed between the groups in satisfaction at the beginning and
12 weeks after taking the medication (p = 0.062 and p = 0.061, respectively) and
in objective improvement of patients and physicians (p = 0.657 and p = 0.748,
respectively). Group A was less disabled and had greater physical health scores
than group B (p = 0.014 and p = 0.017, respectively). CONCLUSIONS: Oral
corticosteroids for the treatment of lumbar radiating pain can be more effective
in pain relief than gabapentin or pregabalin. The satisfaction of patients and
physicians with the drug and objective improvement status were not inferior to
that with gabapentin or pregabalin.
|Adolescent
[MESH]
|Adrenal Cortex Hormones/*therapeutic use
[MESH]
|Adult
[MESH]
|Aged
[MESH]
|Amines/therapeutic use
[MESH]
|Analgesics/therapeutic use
[MESH]
|Cyclohexanecarboxylic Acids/therapeutic use
[MESH]
|Female
[MESH]
|Gabapentin
[MESH]
|Humans
[MESH]
|Low Back Pain/*drug therapy/*physiopathology
[MESH]
|Lumbosacral Region/physiopathology
[MESH]
|Male
[MESH]
|Middle Aged
[MESH]
|Patient Satisfaction/statistics & numerical data
[MESH]