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2016 ; 23
(1
): 65-73
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25-year follow-up after lung transplantation at Lund University Hospital in
Sweden: superior results obtained for patients with cystic fibrosis
#MMPMID27052747
Fakhro M
; Ingemansson R
; Skog I
; Algotsson L
; Hansson L
; Koul B
; Gustafsson R
; Wierup P
; Lindstedt S
Interact Cardiovasc Thorac Surg
2016[Jul]; 23
(1
): 65-73
PMID27052747
show ga
OBJECTIVES: In Sweden, two centres perform lung transplantation for a population
of about 9 million and the entire population is covered for lung transplantation
by government health insurance. Lund University Hospital is one of these centres.
This retrospective report reviews the 25-year experience of the Skåne University
Hospital Lung Transplant Program with particular emphasis on short-term outcome
and long-term survival but also between different subgroups of patients and types
of transplant [single-lung transplantation (SLTx) versus double-lung
transplantation (DLTx)] procedure performed. METHODS: Between January 1990 and
June 2014, 278 patients underwent lung transplantation at the Skåne University
Hospital Sweden. DLTx was performed in 172 patients, SLTx was performed in 97
patients and heart-lung transplantation was performed in 9 patients. In addition,
15 patients required retransplantation (7 DLTx and 8 SLTx). RESULTS: Overall 1-,
5-, 10-, 15- and 20-year survival rates were 88, 65, 49, 37 and 19% for the whole
cohort. DLTx recipients showed 1-, 5-, 10- and 20-year survival rates of 90, 71,
60 and 30%, compared with SLTx recipients with 1-, 5-, 10- and 20-year survival
rates of 83, 57, 34 and 6% (P < 0.05), respectively. Comparing the use of
intraoperative extracorporeal membrane oxygenation, extracorporeal circulation
(ECC) and no circulatory support in the aspect of survival, a significant
difference in favour of intraoperative ECC was seen. CONCLUSIONS: Superior
long-term survival rates were seen in recipients diagnosed with cystic fibrosis,
?1-antitrypsin deficiency and pulmonary hypertension. DLTx showed better results
compared with SLTx especially at 10 years post-transplant. In the present study,
we present cumulative incidence rates of bronchiolitis obliterans syndrome of 15%
at 5 years, 26% at 10 years and 32% at 20 years post-transplant; these figures
are in line with the lowest rates presented internationally.