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10.1038/cdd.2015.128 http://scihub22266oqcxt.onion/10.1038/cdd.2015.128 C4986633!4986633!26564400     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Differ 2016 ; 23 (4): 608-15 Nephropedia Template TP {{tp|p=26564400|t=2016. An RNA interference screen identifies new avenues for nephroprotection |pdf=|usr=}}{{26564400}} gab.com Text An RNA interference screen identifies new avenues for nephroprotection JO: Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=26564400 #FOAvip Acute kidney injury is a major public health problem, which is commonly caused by renal ischemia and is associated with a high risk of mortality and long-term disability. Efforts to develop a treatment for this condition have met with very limited success. We used an RNA interference screen to identify genes (BCL2L14, BLOC1S2, C2ORF42, CPT1A, FBP1, GCNT3, RHOB, SCIN, TACR1, and TNFAIP6) whose suppression improves survival of kidney epithelial cells in in vitro models of oxygen and glucose deprivation. Some of the genes also modulate the toxicity of cisplatin, an anticancer agent whose use is currently limited by nephrotoxicity. Furthermore, pharmacological inhibition of TACR1 product NK1R was protective in a model of mouse renal ischemia, attesting to the in vivo relevance of our findings. These data shed new light on the mechanisms of stress response in mammalian cells, and open new avenues to reduce the morbidity and mortality associated with renal injury. Twit Text FOAVip An RNA interference screen identifies new avenues for nephroprotection ????Cell Death Differ http://www.kidney.de/pget.php?&tw=1&pmid=26564400 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26564400 #FOAvip English Wikipedia <ref>{{Cite pmid|26564400}}</ref> An RNA interference screen identifies new avenues for nephroprotection #MMPMID26564400 Zynda ER; Schott B; Gruener S; Wernher E; Nguyen GD; Ebeling M; Kandel ES Cell Death Differ 2016[Apr]; 23 (4): 608-15 PMID26564400show ga Acute kidney injury is a major public health problem, which is commonly caused by renal ischemia and is associated with a high risk of mortality and long-term disability. Efforts to develop a treatment for this condition have met with very limited success. We used an RNA interference screen to identify genes (BCL2L14, BLOC1S2, C2ORF42, CPT1A, FBP1, GCNT3, RHOB, SCIN, TACR1, and TNFAIP6) whose suppression improves survival of kidney epithelial cells in in vitro models of oxygen and glucose deprivation. Some of the genes also modulate the toxicity of cisplatin, an anticancer agent whose use is currently limited by nephrotoxicity. Furthermore, pharmacological inhibition of TACR1 product NK1R was protective in a model of mouse renal ischemia, attesting to the in vivo relevance of our findings. These data shed new light on the mechanisms of stress response in mammalian cells, and open new avenues to reduce the morbidity and mortality associated with renal injury. äAn RNA interference screen identifies new avenues for nephroprotection(epmc).pdf DeepDyve Pubget Overpricing