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10.1136/bcr-2016-215981

http://scihub22266oqcxt.onion/10.1136/bcr-2016-215981
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C4986154!4986154!27469383
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suck abstract from ncbi


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pmid27469383      BMJ+Case+Rep 2016 ; 2016 (ä): ä
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  • Expanding the range of immunopathology in neuromyelitis optica spectrum disorder #MMPMID27469383
  • Massey J; Buckland ME; Barnett Y; Sutton I
  • BMJ Case Rep 2016[]; 2016 (ä): ä PMID27469383show ga
  • Neuromyelitis optica (NMO) spectrum disorder typically associates with a pathognomonic antibody response directed against aquaporin 4 and a unique immunopathological signature characterised by loss of aquaporin 4 expression. We describe a tumefactive presentation of NMO in which a biopsy specimen demonstrated active demyelination and reactive astrocytes with preserved surface aquaporin 4 immunoreactivity and dystrophic processes. While the astrocytic pathology is more typical of classical multiple sclerosis, a positive NMO-IgG (1:80) and subsequent clinical presentation with an area postrema syndrome is consistent with a diagnosis of NMO spectrum disorder. This report expands the immunopathological features that have been reported in NMO spectrum disorder.
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