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2016 ; 43
(9
): 572-8
Nephropedia Template TP
gab.com Text
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English Wikipedia
Higher HPV16 and HPV18 Penile Viral Loads Are Associated With Decreased Human
Papillomavirus Clearance in Uncircumcised Kenyan Men
#MMPMID27513384
Senkomago V
; Backes DM
; Hudgens MG
; Poole C
; Meshnick SR
; Agot K
; Moses S
; Snijders PJ
; Meijer CJ
; Hesselink AT
; Schlecht NF
; Bailey RC
; Smith JS
Sex Transm Dis
2016[Sep]; 43
(9
): 572-8
PMID27513384
show ga
BACKGROUND: Whether higher penile human papillomavirus (HPV) viral load is
associated with a lower rate of HPV clearance remains unknown. OBJECTIVES: We
examined the association between penile HPV16 and HPV18 viral load and subsequent
HPV clearance in uncircumcised Kenyan men. STUDY DESIGN: Participants were human
immunodeficiency virus (HIV)-seronegative, sexually active, 18- to 24-year-old
men randomized to the control arm of a male circumcision trial in Kisumu, Kenya.
Men provided exfoliated penile cells from two anatomical sites (glans/coronal
sulcus and shaft) every 6 months for 2 years. GP5+/6+ polymerase chain reaction
was used to identify 44 HPV-DNA types. Human papillomavirus viral load testing
was conducted using a LightCyler real-time polymerase chain reaction assay; viral
load was classified as high (>250 copies/scrape) or low (?250 copies/scrape), for
nonquantifiable values. The Kaplan-Meier method and Cox regression modeling were
used to examine the association between HPV viral load and HPV clearance.
RESULTS: A total of 1097 men, with 291 HPV16 and 131 HPV18 cumulative infections
over 24 months were analyzed. Human papillomavirus clearance at 6 months after
first HPV detection was lower for high versus low viral load HPV16 infections in
the glans (adjusted hazard ratio [aHR], 0.65; 95% confidence interval [CI],
0.46-0.92)] and shaft (aHR, 0.44; 95% CI, 0.16-0.90), and HPV18 infections in the
glans (aHR, 0.05; 95% CI, 0.01-0.17). DISCUSSION: High versus low HPV viral load
was associated with a reduced HPV clearance for HPV16 infections in the glans and
shaft, and for HPV18 infections in the glans, among young uncircumcised men.
Reduced clearance of high viral load HPV16 and HPV18 infections in men may
increase HPV transmission to their female partners as well as enhance the
development of penile lesions in comparison to men with low viral load HPV
infections.