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10.1080/21541264.2016.1181142

http://scihub22266oqcxt.onion/10.1080/21541264.2016.1181142
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C4984685!4984685!27100743
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suck abstract from ncbi


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pmid27100743      Transcription 2016 ; 7 (3): 75-83
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  • A critical role for topoisomerase IIb and DNA double strand breaks in transcription #MMPMID27100743
  • Calderwood SK
  • Transcription 2016[May]; 7 (3): 75-83 PMID27100743show ga
  • Recent studies have indicated a novel role for topoisomerase IIb in transcription. Transcription of heat shock genes, serum-induced immediate early genes and nuclear receptor-activated genes, each required DNA double strands generated by topoisomerase IIb. Such strand breaks seemed both necessary and sufficient for transcriptional activation. In addition, such transcription was associated with initiation of the DNA damage response pathways, including the activation of the enzymes: ataxia-telangiectasia mutated (ATM), DNA-dependent protein kinase and poly (ADP ribose) polymerase 1. DNA damage response signaling was involved both in transcription and in repair of DNA breaks generated by topoisomerase IIb.
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