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A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/bjc.2016.147 http://scihub22266oqcxt.onion/10.1038/bjc.2016.147 C4984472!4984472 !27228299     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27228299 &cmd=llinks): Failed to open stream: HTTP request failed! 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Risk factors of proteinuria in renal cell carcinoma patients treated with VEGF inhibitors: a secondary analysis of pooled clinical trial data |pdf=|usr=}}{{27228299 }} gab.com Text Risk factors of proteinuria in renal cell carcinoma patients treated with VEGF inhibitors: a secondary analysis of pooled clinical trial data JO: Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=27228299 #FOAvip BACKGROUND: Proteinuria is a common adverse effect of vascular endothelial growth factor targeted agents, particularly in metastatic renal cell carcinoma (mRCC). However, risk factors for proteinuria are poorly defined. METHODS: Data on 1392 mRCC patients using pazopanib or sunitinib were pooled from two Phase-III clinical trials. Risk factors and prognostic effect of on-therapy proteinuria were evaluated by Cox proportional hazards regression. RESULTS: Any-grade (1-4) and grade 3/4 proteinuria incidence were 15.0% and 3.7%, respectively. Asian ethnicity, diabetes, baseline systolic blood pressure (SBP), pre-existing grade 1 proteinuria and prior nephrectomy were significant independent predictors of either any-grade or grade 3/4 proteinuria. Proteinuria, particularly grade 3/4 (adjusted hazard ratio 0.53 (95% confidence interval 0.30-0.92)), was associated with improved overall survival. CONCLUSIONS: In mRCC patients using pazopanib or sunitinib, Asian ethnicity, diabetes, SBP, pre-existing proteinuria and prior nephrectomy were independent predictors of on-therapy proteinuria, which was associated with improved survival. Twit Text FOAVip Risk factors of proteinuria in renal cell carcinoma patients treated with VEGF inhibitors: a secondary analysis of pooled clinical trial data ????Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=27228299 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27228299 #FOAvip English Wikipedia <ref>{{Cite pmid|27228299 }}</ref> Risk factors of proteinuria in renal cell carcinoma patients treated with VEGF inhibitors: a secondary analysis of pooled clinical trial data #MMPMID27228299 Sorich MJ ; Rowland A ; Kichenadasse G ; Woodman RJ ; Mangoni AA Br J Cancer 2016[Jun]; 114 (12 ): 1313-7 PMID27228299 show ga BACKGROUND: Proteinuria is a common adverse effect of vascular endothelial growth factor targeted agents, particularly in metastatic renal cell carcinoma (mRCC). However, risk factors for proteinuria are poorly defined. METHODS: Data on 1392 mRCC patients using pazopanib or sunitinib were pooled from two Phase-III clinical trials. Risk factors and prognostic effect of on-therapy proteinuria were evaluated by Cox proportional hazards regression. RESULTS: Any-grade (1-4) and grade 3/4 proteinuria incidence were 15.0% and 3.7%, respectively. Asian ethnicity, diabetes, baseline systolic blood pressure (SBP), pre-existing grade 1 proteinuria and prior nephrectomy were significant independent predictors of either any-grade or grade 3/4 proteinuria. Proteinuria, particularly grade 3/4 (adjusted hazard ratio 0.53 (95% confidence interval 0.30-0.92)), was associated with improved overall survival. CONCLUSIONS: In mRCC patients using pazopanib or sunitinib, Asian ethnicity, diabetes, SBP, pre-existing proteinuria and prior nephrectomy were independent predictors of on-therapy proteinuria, which was associated with improved survival. |Carcinoma, Renal Cell/*drug therapy/*urine [MESH] |Female [MESH] |Humans [MESH] |Indazoles [MESH] |Indoles/adverse effects/*therapeutic use [MESH] |Kidney Neoplasms/*drug therapy/*urine [MESH] |Male [MESH] |Middle Aged [MESH] |Proportional Hazards Models [MESH] |Proteinuria/*chemically induced [MESH] |Pyrimidines/adverse effects/*therapeutic use [MESH] |Pyrroles/adverse effects/*therapeutic use [MESH] |Risk Factors [MESH] |Sulfonamides/adverse effects/*therapeutic use [MESH] |Sunitinib [MESH] |Survival Analysis [MESH]Risk factors of proteinuria in renal cell carcinoma patients treated w(epmc).pdf DeepDyve Pubget Overpricing