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10.1073/pnas.1604529113 http://scihub22266oqcxt.onion/10.1073/pnas.1604529113 C4983837!4983837 !27099294     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27099294 &cmd=llinks): Failed to open stream: HTTP request failed! 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Canonical NF-?B signaling is uniquely required for the long-term persistence of functional mature B cells |pdf=|usr=}}{{27099294 }} gab.com Text Canonical NF- B signaling is uniquely required for the long-term persistence of functional mature B cells JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27099294 #FOAvip Although canonical NF-?B signaling is crucial to generate a normal mature B-cell compartment, its role in the persistence of resting mature B cells is controversial. To resolve this conflict, we ablated NF-?B essential modulator (NEMO) and I?B kinase 2 (IKK2), two essential mediators of the canonical pathway, either early on in B-cell development or specifically in mature B cells. Early ablation severely inhibited the generation of all mature B-cell subsets, but follicular B-cell numbers could be largely rescued by ectopic expression of B-cell lymphoma 2 (Bcl2), despite a persisting block at the transitional stage. Marginal zone (MZ) B and B1 cells were not rescued, indicating a possible role of canonical NF-?B signals beyond the control of cell survival in these subsets. When canonical NF-?B signaling was ablated specifically in mature B cells, the differentiation and/or persistence of MZ B cells was still abrogated, but follicular B-cell numbers were only mildly affected. However, the mutant cells exhibited increased turnover as well as functional deficiencies upon activation, suggesting that canonical NF-?B signals contribute to their long-term persistence and functional fitness. Twit Text FOAVip Canonical NF- B signaling is uniquely required for the long-term persistence of functional mature B cells ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27099294 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27099294 #FOAvip English Wikipedia <ref>{{Cite pmid|27099294 }}</ref> Canonical NF-?B signaling is uniquely required for the long-term persistence of functional mature B cells #MMPMID27099294 Derudder E ; Herzog S ; Labi V ; Yasuda T ; Köchert K ; Janz M ; Villunger A ; Schmidt-Supprian M ; Rajewsky K Proc Natl Acad Sci U S A 2016[May]; 113 (18 ): 5065-70 PMID27099294 show ga Although canonical NF-?B signaling is crucial to generate a normal mature B-cell compartment, its role in the persistence of resting mature B cells is controversial. To resolve this conflict, we ablated NF-?B essential modulator (NEMO) and I?B kinase 2 (IKK2), two essential mediators of the canonical pathway, either early on in B-cell development or specifically in mature B cells. Early ablation severely inhibited the generation of all mature B-cell subsets, but follicular B-cell numbers could be largely rescued by ectopic expression of B-cell lymphoma 2 (Bcl2), despite a persisting block at the transitional stage. Marginal zone (MZ) B and B1 cells were not rescued, indicating a possible role of canonical NF-?B signals beyond the control of cell survival in these subsets. When canonical NF-?B signaling was ablated specifically in mature B cells, the differentiation and/or persistence of MZ B cells was still abrogated, but follicular B-cell numbers were only mildly affected. However, the mutant cells exhibited increased turnover as well as functional deficiencies upon activation, suggesting that canonical NF-?B signals contribute to their long-term persistence and functional fitness. |Animals [MESH] |B-Lymphocytes/*cytology/*immunology [MESH] |Cell Survival/*immunology [MESH] |Cells, Cultured [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |NF-kappa B/*immunology [MESH]Canonical NF-?B signaling is uniquely required for the long-term persi(epmc).pdf DeepDyve Pubget Overpricing