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10.1073/pnas.1523005113 http://scihub22266oqcxt.onion/10.1073/pnas.1523005113 C4983815!4983815 !27091985     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27091985 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (18 ): E2516-25 Nephropedia Template TP {{tp|p=27091985 |t=2016. Comparative systems pharmacology of HIF stabilization in the prevention of retinopathy of prematurity |pdf=|usr=}}{{27091985 }} gab.com Text Comparative systems pharmacology of HIF stabilization in the prevention of retinopathy of prematurity JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27091985 #FOAvip Retinopathy of prematurity (ROP) causes 100,000 new cases of childhood blindness each year. ROP is initiated by oxygen supplementation necessary to prevent neonatal death. We used organ systems pharmacology to define the transcriptomes of mice that were cured of oxygen-induced retinopathy (OIR, ROP model) by hypoxia-inducible factor (HIF) stabilization via HIF prolyl hydroxylase inhibition using the isoquinolone Roxadustat or the 2-oxoglutarate analog dimethyloxalylglycine (DMOG). Although both molecules conferred a protective phenotype, gene expression analysis by RNA sequencing found that Roxadustat can prevent OIR by two pathways: direct retinal HIF stabilization and induction of aerobic glycolysis or indirect hepatic HIF-1 stabilization and increased serum angiokines. As predicted by pathway analysis, Roxadustat rescued the hepatic HIF-1 knockout mouse from retinal oxygen toxicity, whereas DMOG could not. The simplicity of systemic treatment that targets both the liver and the eye provides a rationale for protecting the severely premature infant from oxygen toxicity. Twit Text FOAVip Comparative systems pharmacology of HIF stabilization in the prevention of retinopathy of prematurity ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27091985 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27091985 #FOAvip English Wikipedia <ref>{{Cite pmid|27091985 }}</ref> Comparative systems pharmacology of HIF stabilization in the prevention of retinopathy of prematurity #MMPMID27091985 Hoppe G ; Yoon S ; Gopalan B ; Savage AR ; Brown R ; Case K ; Vasanji A ; Chan ER ; Silver RB ; Sears JE Proc Natl Acad Sci U S A 2016[May]; 113 (18 ): E2516-25 PMID27091985 show ga Retinopathy of prematurity (ROP) causes 100,000 new cases of childhood blindness each year. ROP is initiated by oxygen supplementation necessary to prevent neonatal death. We used organ systems pharmacology to define the transcriptomes of mice that were cured of oxygen-induced retinopathy (OIR, ROP model) by hypoxia-inducible factor (HIF) stabilization via HIF prolyl hydroxylase inhibition using the isoquinolone Roxadustat or the 2-oxoglutarate analog dimethyloxalylglycine (DMOG). Although both molecules conferred a protective phenotype, gene expression analysis by RNA sequencing found that Roxadustat can prevent OIR by two pathways: direct retinal HIF stabilization and induction of aerobic glycolysis or indirect hepatic HIF-1 stabilization and increased serum angiokines. As predicted by pathway analysis, Roxadustat rescued the hepatic HIF-1 knockout mouse from retinal oxygen toxicity, whereas DMOG could not. The simplicity of systemic treatment that targets both the liver and the eye provides a rationale for protecting the severely premature infant from oxygen toxicity. |Animals [MESH] |Dose-Response Relationship, Drug [MESH] |Glycine/administration & dosage/*analogs & derivatives [MESH] |Hypoxia-Inducible Factor 1/antagonists & inhibitors/*metabolism [MESH] |Isoquinolines/*administration & dosage [MESH] |Liver/drug effects/*metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Retina/drug effects/*metabolism [MESH] |Retinopathy of Prematurity/*drug therapy/*prevention & control [MESH] |Transcriptome/*drug effects [MESH]Comparative systems pharmacology of HIF stabilization in the preventio(epmc).pdf DeepDyve Pubget Overpricing