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Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (18): 5071-6 Nephropedia Template TP
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Dysregulation of a family of short noncoding RNAs, tsRNAs, in human cancer #MMPMID27071132
Proc Natl Acad Sci U S A 2016[May]; 113 (18): 5071-6 PMID27071132show ga
Chronic lymphocytic leukemia (CLL) is the most common human leukemia. We identified two members of the tRNA-derived small RNA (tsRNA) family, ts-3676 and ts-4521, both inactivated in CLL and lung cancer. We further analyzed expression of 120 tsRNAs and found that tsRNAs are dysregulated in CLL and lung cancer. Thus this study uncovers the involvement of this recently identified class of small, non-coding RNAs in hematopoietic malignancies and solid tumors.