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10.1016/j.coviro.2016.06.002 http://scihub22266oqcxt.onion/10.1016/j.coviro.2016.06.002 C4983487!4983487!27318434     free     free     free       Curr+Opin+Virol 2016 ; 18 (ä): 117-25 Nephropedia Template TP {{tp|p=27318434|t=2016. Antiviral Targets of Human Noroviruses |pdf=|usr=}}{{27318434}} gab.com Text Antiviral Targets of Human Noroviruses JO: Curr Opin Virol http://www.kidney.de/pget.php?&tw=1&pmid=27318434 #FOAvip Human noroviruses are major causative agents of sporadic and epidemic gastroenteritis both in children and adults. Currently there are no licensed therapeutic intervention measures either in terms of vaccines or drugs available for these highly contagious human pathogens. Genetic and antigenic diversity of these viruses, rapid emergence of new strains, and their ability to infect a broad population by using polymorphic histo-blood group antigens for cell attachment, pose significant challenges for the development of effective antiviral agents. Despite these impediments, there is progress in the design and development of therapeutic agents. These include capsid-based candidate vaccines, and potential antivirals either in the form of glycomimetics or designer antibodies that block HBGA binding, as well as those that target essential non-structural proteins such as the viral protease and RNA-dependent RNA polymerase. In addition to these classical approaches, recent studies suggest the possibility of interferons and targeting host cell factors as viable approaches to counter norovirus infection. This review provides a brief overview of this progress. Twit Text FOAVip Antiviral Targets of Human Noroviruses ????Curr Opin Virol http://www.kidney.de/pget.php?&tw=1&pmid=27318434 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27318434 #FOAvip English Wikipedia <ref>{{Cite pmid|27318434}}</ref> Antiviral Targets of Human Noroviruses #MMPMID27318434 Venkataram Prasad BV; Shanker S; Muhaxhiri Z; Deng L; Choi JM; Estes MK; Song Y; Palzkill T; Atmar RL Curr Opin Virol 2016[Jun]; 18 (ä): 117-25 PMID27318434show ga Human noroviruses are major causative agents of sporadic and epidemic gastroenteritis both in children and adults. Currently there are no licensed therapeutic intervention measures either in terms of vaccines or drugs available for these highly contagious human pathogens. Genetic and antigenic diversity of these viruses, rapid emergence of new strains, and their ability to infect a broad population by using polymorphic histo-blood group antigens for cell attachment, pose significant challenges for the development of effective antiviral agents. Despite these impediments, there is progress in the design and development of therapeutic agents. These include capsid-based candidate vaccines, and potential antivirals either in the form of glycomimetics or designer antibodies that block HBGA binding, as well as those that target essential non-structural proteins such as the viral protease and RNA-dependent RNA polymerase. In addition to these classical approaches, recent studies suggest the possibility of interferons and targeting host cell factors as viable approaches to counter norovirus infection. This review provides a brief overview of this progress. äAntiviral Targets of Human Noroviruses (epmc).pdf DeepDyve Pubget Overpricing