Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27396816
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Autoimmun+Rev
2016 ; 15
(9
): 923-30
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Non-infectious environmental antigens as a trigger for the initiation of an
autoimmune skin disease
#MMPMID27396816
Qian Y
; Culton DA
; Jeong JS
; Trupiano N
; Valenzuela JG
; Diaz LA
Autoimmun Rev
2016[Sep]; 15
(9
): 923-30
PMID27396816
show ga
Pemphigus represents a group of organ specific autoimmune blistering disorders of
the skin mediated by pathogenic autoantibodies with well-defined antigenic
targets. While most of these diseases are sporadic, endemic forms of disease do
exist. The endemic form of pemphigus foliaceus (also known as fogo selvagem, FS)
exhibits epidemiological features that suggest exposure to hematophagous insect
bites are a possible precipitating factor of this autoimmune disease, and
provides a unique opportunity to study how environmental factors contribute to
autoimmune disease development. FS patients and healthy individuals from endemic
regions show an autoreactive IgM response that starts in early childhood and
becomes restricted to IgG4 autoantibodies in FS patients. In searching for
triggering environmental antigens, we have found that IgG4 and IgE autoantibodies
from FS patients cross-react with a salivary antigen from sand flies. The
presence of these cross-reactive antibodies and antibody genetic analysis
confirming that these antibodies evolve from the same naïve B cells provides
compelling evidence that this non-infectious environmental antigen could be the
initial target of the autoantibody response in FS. Consequently, FS serves as an
ideal model to study the impact of environmental antigens in the development of
autoimmune disease.