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10.1007/s10863-016-9652-1 http://scihub22266oqcxt.onion/10.1007/s10863-016-9652-1 C4981558!4981558!26868013     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Bioenerg+Biomembr 2017 ; 49 (1): 13-25 Nephropedia Template TP {{tp|p=26868013|t=2017. Physiological roles of the mitochondrial permeability transition pore |pdf=|usr=}}{{26868013}} gab.com Text Physiological roles of the mitochondrial permeability transition pore JO: J Bioenerg Biomembr http://www.kidney.de/pget.php?&tw=1&pmid=26868013 #FOAvip Neurons experience high metabolic demand during such processes as synaptic vesicle recycling, membrane potential maintenance and Ca2+ exchange/extrusion. The energy needs of these events are met in large part by mitochondrial production of ATP through the process of oxidative phosphorylation. The job of ATP production by the mitochondria is performed by the F1FO ATP synthase, a multi-protein enzyme that contains a membrane-inserted portion, an extra-membranous enzymatic portion and an extensive regulatory complex. Although required for ATP production by mitochondria, recent findings have confirmed that the membrane-confined portion of the c-subunit of the ATP synthase also houses a large conductance uncoupling channel, the mitochondrial permeability transition pore (mPTP), the persistent opening of which produces osmotic dysregulation of the inner mitochondrial membrane, uncoupling of oxidative phosphorylation and cell death. Recent advances in understanding the molecular components of mPTP and its regulatory mechanisms have determined that decreased uncoupling occurs in states of enhanced mitochondrial efficiency; relative closure of mPTP therefore contributes to cellular functions as diverse as cardiac development and synaptic efficacy. Twit Text FOAVip Physiological roles of the mitochondrial permeability transition pore ????J Bioenerg Biomembr http://www.kidney.de/pget.php?&tw=1&pmid=26868013 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26868013 #FOAvip English Wikipedia <ref>{{Cite pmid|26868013}}</ref> Physiological roles of the mitochondrial permeability transition pore #MMPMID26868013 Mnatsakanyan N; Beutner G; Porter GA; Alavian KN; Jonas EA J Bioenerg Biomembr 2017[Feb]; 49 (1): 13-25 PMID26868013show ga Neurons experience high metabolic demand during such processes as synaptic vesicle recycling, membrane potential maintenance and Ca2+ exchange/extrusion. The energy needs of these events are met in large part by mitochondrial production of ATP through the process of oxidative phosphorylation. The job of ATP production by the mitochondria is performed by the F1FO ATP synthase, a multi-protein enzyme that contains a membrane-inserted portion, an extra-membranous enzymatic portion and an extensive regulatory complex. Although required for ATP production by mitochondria, recent findings have confirmed that the membrane-confined portion of the c-subunit of the ATP synthase also houses a large conductance uncoupling channel, the mitochondrial permeability transition pore (mPTP), the persistent opening of which produces osmotic dysregulation of the inner mitochondrial membrane, uncoupling of oxidative phosphorylation and cell death. Recent advances in understanding the molecular components of mPTP and its regulatory mechanisms have determined that decreased uncoupling occurs in states of enhanced mitochondrial efficiency; relative closure of mPTP therefore contributes to cellular functions as diverse as cardiac development and synaptic efficacy. äPhysiological roles of the mitochondrial permeability transition pore (epmc).pdf DeepDyve Pubget Overpricing