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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Ther+Adv+Med+Oncol 2016 ; 8 (5): 375-82 Nephropedia Template TP
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Hedgehog pathway inhibition in advanced basal cell carcinoma: latest evidence and clinical usefulness #MMPMID27583029
Silapunt S; Chen L; Migden MR
Ther Adv Med Oncol 2016[Sep]; 8 (5): 375-82 PMID27583029show ga
Treatment of locally advanced basal cell carcinomas (laBCCs) with large, aggressive, destructive, and disfiguring tumors, or metastatic disease is challenging. Dysregulation of the Hedgehog (Hh) signaling pathway has been identified in the vast majority of basal cell carcinomas (BCCs). There are two United States Food and Drug Administration (US FDA)-approved Hh pathway inhibitors (HPIs) that exhibit antitumor activity in advanced BCC with an acceptable safety profile. Common adverse effects include muscle spasms, dysgeusia, alopecia, fatigue, nausea and weight loss.