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10.1177/1758834016653605

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C4981290!4981290!27583029
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suck abstract from ncbi


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pmid27583029      Ther+Adv+Med+Oncol 2016 ; 8 (5): 375-82
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  • Hedgehog pathway inhibition in advanced basal cell carcinoma: latest evidence and clinical usefulness #MMPMID27583029
  • Silapunt S; Chen L; Migden MR
  • Ther Adv Med Oncol 2016[Sep]; 8 (5): 375-82 PMID27583029show ga
  • Treatment of locally advanced basal cell carcinomas (laBCCs) with large, aggressive, destructive, and disfiguring tumors, or metastatic disease is challenging. Dysregulation of the Hedgehog (Hh) signaling pathway has been identified in the vast majority of basal cell carcinomas (BCCs). There are two United States Food and Drug Administration (US FDA)-approved Hh pathway inhibitors (HPIs) that exhibit antitumor activity in advanced BCC with an acceptable safety profile. Common adverse effects include muscle spasms, dysgeusia, alopecia, fatigue, nausea and weight loss.
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