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2016 ; 8
(5
): 375-82
Nephropedia Template TP
gab.com Text
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English Wikipedia
Hedgehog pathway inhibition in advanced basal cell carcinoma: latest evidence and
clinical usefulness
#MMPMID27583029
Silapunt S
; Chen L
; Migden MR
Ther Adv Med Oncol
2016[Sep]; 8
(5
): 375-82
PMID27583029
show ga
Treatment of locally advanced basal cell carcinomas (laBCCs) with large,
aggressive, destructive, and disfiguring tumors, or metastatic disease is
challenging. Dysregulation of the Hedgehog (Hh) signaling pathway has been
identified in the vast majority of basal cell carcinomas (BCCs). There are two
United States Food and Drug Administration (US FDA)-approved Hh pathway
inhibitors (HPIs) that exhibit antitumor activity in advanced BCC with an
acceptable safety profile. Common adverse effects include muscle spasms,
dysgeusia, alopecia, fatigue, nausea and weight loss.