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10.1007/s10549-016-3876-y http://scihub22266oqcxt.onion/10.1007/s10549-016-3876-y C4979600!4979600!27372070     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Breast+Cancer+Res+Treat 2016 ; 158 (2): 219-32 Nephropedia Template TP {{tp|p=27372070|t=2016. Recurrent and pathological gene fusions in breast cancer: current advances in genomic discovery and clinical implications |pdf=|usr=}}{{27372070}} gab.com Text Recurrent and pathological gene fusions in breast cancer: current advances in genomic discovery and clinical implications JO: Breast Cancer Res Treat http://www.kidney.de/pget.php?&tw=1&pmid=27372070 #FOAvip Gene fusions have long been considered principally as the oncogenic events of hematologic malignancies, but have recently gained wide attention in solid tumors due to several milestone discoveries and the advancement of deep sequencing technologies. With the progress in deep sequencing studies of breast cancer transcriptomes and genomes, the discovery of recurrent and pathological gene fusions in breast cancer is on the focus. Recently, driven by new deep sequencing studies, several recurrent or pathological gene fusions have been identified in breast cancer, including ESR1-CCDC170, SEC16A-NOTCH1, SEC22B-NOTCH2 and ESR1-YAP1, etc. More important, most of these gene fusions are preferentially identified in the more aggressive breast cancers such as luminal B, basal like, or endocrine resistant breast cancer, suggesting recurrent gene fusions as additional key driver events in these tumors other than the known drivers such as the estrogen-receptor. In this paper, we have comprehensively summarized the newly identified recurrent or pathological gene fusion events in breast cancer, reviewed the contributions of new genomic and deep sequencing technologies to new fusion discovery and the integrative bioinformatics tools to analyze these data, highlighted the biological relevance and clinical implications of these fusion discoveries, and discussed future directions of gene fusion research in breast cancer. Twit Text FOAVip Recurrent and pathological gene fusions in breast cancer: current advances in genomic discovery and clinical implications ????Breast Cancer Res Treat http://www.kidney.de/pget.php?&tw=1&pmid=27372070 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27372070 #FOAvip English Wikipedia <ref>{{Cite pmid|27372070}}</ref> Recurrent and pathological gene fusions in breast cancer: current advances in genomic discovery and clinical implications #MMPMID27372070 Veeraraghavan J; Ma J; Hu Y; Wang XS Breast Cancer Res Treat 2016[Jul]; 158 (2): 219-32 PMID27372070show ga Gene fusions have long been considered principally as the oncogenic events of hematologic malignancies, but have recently gained wide attention in solid tumors due to several milestone discoveries and the advancement of deep sequencing technologies. With the progress in deep sequencing studies of breast cancer transcriptomes and genomes, the discovery of recurrent and pathological gene fusions in breast cancer is on the focus. Recently, driven by new deep sequencing studies, several recurrent or pathological gene fusions have been identified in breast cancer, including ESR1-CCDC170, SEC16A-NOTCH1, SEC22B-NOTCH2 and ESR1-YAP1, etc. More important, most of these gene fusions are preferentially identified in the more aggressive breast cancers such as luminal B, basal like, or endocrine resistant breast cancer, suggesting recurrent gene fusions as additional key driver events in these tumors other than the known drivers such as the estrogen-receptor. In this paper, we have comprehensively summarized the newly identified recurrent or pathological gene fusion events in breast cancer, reviewed the contributions of new genomic and deep sequencing technologies to new fusion discovery and the integrative bioinformatics tools to analyze these data, highlighted the biological relevance and clinical implications of these fusion discoveries, and discussed future directions of gene fusion research in breast cancer. äRecurrent and pathological gene fusions in breast cancer: current adva(epmc).pdf DeepDyve Pubget Overpricing