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10.4155/fmc.15.189 http://scihub22266oqcxt.onion/10.4155/fmc.15.189 C4976882!4976882!26910612     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Future+Med+Chem 2016 ; 8 (3): 257-69 Nephropedia Template TP {{tp|p=26910612|t=2016. NH125 kills methicillin-resistant Staphylococcus aureus persisters by lipid bilayer disruption |pdf=|usr=}}{{26910612}} gab.com Text NH125 kills methicillin-resistant Staphylococcus aureus persisters by lipid bilayer disruption JO: Future Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=26910612 #FOAvip Background:: NH125, a known WalK inhibitor kills MRSA persisters. However, its precise mode of action is still unknown. Methods & results:: The mode of action of NH125 was investigated by comparing its spectrum of antimicrobial activity and its effects on membrane permeability and giant unilamellar vesicles (GUVs) with walrycin B, a WalR inhibitor and benzyldimethylhexadecylammonium chloride (16-BAC), a cationic surfactant. NH125 killed persister cells of a variety of Staphylococcus aureus strains. Similar to 16-BAC, NH125 killed MRSA persisters by inducing rapid membrane permeabilization and caused the rupture of GUVs, whereas walrycin B did not kill MRSA persisters or induce membrane permeabilization and did not affect GUVs. Conclusion:: NH125 kills MRSA persisters by interacting with and disrupting membranes in a detergent-like manner. Twit Text FOAVip NH125 kills methicillin-resistant Staphylococcus aureus persisters by lipid bilayer disruption ????Future Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=26910612 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26910612 #FOAvip English Wikipedia <ref>{{Cite pmid|26910612}}</ref> NH125 kills methicillin-resistant Staphylococcus aureus persisters by lipid bilayer disruption #MMPMID26910612 Kim W; Fricke N; Conery AL; Fuchs BB; Rajamuthiah R; Jayamani E; Vlahovska PM; Ausubel FM; Mylonakis E Future Med Chem 2016[Mar]; 8 (3): 257-69 PMID26910612show ga Background:: NH125, a known WalK inhibitor kills MRSA persisters. However, its precise mode of action is still unknown. Methods & results:: The mode of action of NH125 was investigated by comparing its spectrum of antimicrobial activity and its effects on membrane permeability and giant unilamellar vesicles (GUVs) with walrycin B, a WalR inhibitor and benzyldimethylhexadecylammonium chloride (16-BAC), a cationic surfactant. NH125 killed persister cells of a variety of Staphylococcus aureus strains. Similar to 16-BAC, NH125 killed MRSA persisters by inducing rapid membrane permeabilization and caused the rupture of GUVs, whereas walrycin B did not kill MRSA persisters or induce membrane permeabilization and did not affect GUVs. Conclusion:: NH125 kills MRSA persisters by interacting with and disrupting membranes in a detergent-like manner. äNH125 kills methicillin-resistant Staphylococcus aureus persisters by (epmc).pdf DeepDyve Pubget Overpricing