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10.4155/fmc.15.134 http://scihub22266oqcxt.onion/10.4155/fmc.15.134 C4976848!4976848!26619226     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Future+Med+Chem 2015 ; 7 (17): 2385-405 Nephropedia Template TP {{tp|p=26619226|t=2015. Triple reuptake inhibitors as potential next-generation antidepressants: a new hope?|pdf=|usr=}}{{26619226}} gab.com Text Triple reuptake inhibitors as potential next-generation antidepressants: a new hope JO: Future Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=26619226 #FOAvip The current therapy for depression is less than ideal with remission rates of only 25?35% and a slow onset of action with other associated side effects. The persistence of anhedonia originating from depressed dopaminergic activity is one of the most treatment-resistant symptoms of depression. Therefore, it has been hypothesized that triple reuptake inhibitors (TRIs) with potency to block dopamine reuptake in addition to serotonin and norepinephrine transporters should produce higher efficacy. The current review comprehensively describes the development of TRIs and discusses the importance of evaluation of in vivo transporter occupancy of TRIs, which should correlate with efficacy in humans. Twit Text FOAVip Triple reuptake inhibitors as potential next-generation antidepressants: a new hope ????Future Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=26619226 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26619226 #FOAvip English Wikipedia <ref>{{Cite pmid|26619226}}</ref> Triple reuptake inhibitors as potential next-generation antidepressants: a new hope? #MMPMID26619226 Sharma H; Santra S; Dutta A Future Med Chem 2015[Nov]; 7 (17): 2385-405 PMID26619226show ga The current therapy for depression is less than ideal with remission rates of only 25?35% and a slow onset of action with other associated side effects. The persistence of anhedonia originating from depressed dopaminergic activity is one of the most treatment-resistant symptoms of depression. Therefore, it has been hypothesized that triple reuptake inhibitors (TRIs) with potency to block dopamine reuptake in addition to serotonin and norepinephrine transporters should produce higher efficacy. The current review comprehensively describes the development of TRIs and discusses the importance of evaluation of in vivo transporter occupancy of TRIs, which should correlate with efficacy in humans. äTriple reuptake inhibitors as potential next-generation antidepressant(epmc).pdf DeepDyve Pubget Overpricing