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Relationship Between Antihypertensive Medications and Cognitive Impairment: Part I Review of Human Studies and Clinical Trials #MMPMID27492370
Yasar S; Schuchman M; Peters J; Anstey KJ; Carlson MC; Peters R
Curr Hypertens Rep 2016[]; 18 (ä): ä PMID27492370show ga
Purpose of review: There is an established association between hypertension and increased risk of poor cognitive performance and dementia including Alzheimer?s disease; however, associations between antihypertensive medications (AHMs) and dementia risk are less consistent. An increased interest in AHM has resulted in expanding publications; however, none of the recent reviews are comprehensive. Our extensive review includes 15 observational and randomized controlled trials (RCTs) published over the last 5 years, assessing the relationship between AHM and cognitive impairment. Recent findings: All classes of AHM showed similar result patterns in human studies with the majority of study results reporting point estimates below one and only a small number of studies (N?=?15) reporting statistically significant results in favor of a specific class. Summary: Only a small number of studies reported statistically significant results in favor of a specific class of AHM. Methodological limitations of the studies prevent definitive conclusions. Further work is now needed to evaluate the class of AHM and cognitive outcomes in future RCTs, with a particular focus on the drugs with the promising results in both animals and human observational studies. Electronic supplementary material: The online version of this article (doi:10.1007/s11906-016-0674-1) contains supplementary material, which is available to authorized users.