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10.1016/j.bbagrm.2016.02.006 http://scihub22266oqcxt.onion/10.1016/j.bbagrm.2016.02.006 C4975672!4975672!26877237     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochim+Biophys+Acta 2016 ; 1859 (9): 1130-40 Nephropedia Template TP {{tp|p=26877237|t=2016. Mechanisms of Xenobiotic Receptor Activation: Direct vs Indirect |pdf=|usr=}}{{26877237}} gab.com Text Mechanisms of Xenobiotic Receptor Activation: Direct vs Indirect JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=26877237 #FOAvip The so-called xenobiotic receptors (XRs) have functionally evolved into cellular sensors for both endogenous and exogenous stimuli by regulating the transcription of genes encoding drug-metabolizing enzymes and transporters, as well as those involving energy homeostasis, cell proliferation, and/or immune responses. Unlike prototypical steroid hormone receptors, XRs are activated through both direct ligand-binding and ligand-independent (indirect) mechanisms by a plethora of structurally unrelated chemicals. This review covers research literature that discusses direct vs. indirect activation of XRs. A particular focus is centered on the signaling control of the constitutive androstane receptor (CAR), the pregnane X receptor (PXR) and the aryl hydrocarbon receptor (AhR). We expect that this review will shed light on both the common and distinct mechanisms associated with activation of these three XRs. Twit Text FOAVip Mechanisms of Xenobiotic Receptor Activation: Direct vs Indirect ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=26877237 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26877237 #FOAvip English Wikipedia <ref>{{Cite pmid|26877237}}</ref> Mechanisms of Xenobiotic Receptor Activation: Direct vs Indirect #MMPMID26877237 Mackowiak B; Wang H Biochim Biophys Acta 2016[Sep]; 1859 (9): 1130-40 PMID26877237show ga The so-called xenobiotic receptors (XRs) have functionally evolved into cellular sensors for both endogenous and exogenous stimuli by regulating the transcription of genes encoding drug-metabolizing enzymes and transporters, as well as those involving energy homeostasis, cell proliferation, and/or immune responses. Unlike prototypical steroid hormone receptors, XRs are activated through both direct ligand-binding and ligand-independent (indirect) mechanisms by a plethora of structurally unrelated chemicals. This review covers research literature that discusses direct vs. indirect activation of XRs. A particular focus is centered on the signaling control of the constitutive androstane receptor (CAR), the pregnane X receptor (PXR) and the aryl hydrocarbon receptor (AhR). We expect that this review will shed light on both the common and distinct mechanisms associated with activation of these three XRs. äMechanisms of Xenobiotic Receptor Activation: Direct vs Indirect (epmc).pdf DeepDyve Pubget Overpricing