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10.1016/j.bbagrm.2016.02.013 http://scihub22266oqcxt.onion/10.1016/j.bbagrm.2016.02.013 C4975625!4975625!26921498     free     free     free       Biochim+Biophys+Acta 2016 ; 1859 (9): 1141-54 Nephropedia Template TP {{tp|p=26921498|t=2016. Small-molecule modulators of PXR and CAR |pdf=|usr=}}{{26921498}} gab.com Text Small-molecule modulators of PXR and CAR JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=26921498 #FOAvip Two nuclear receptors, the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR), participate in the xenobiotic detoxification system by regulating the expression of drug-metabolizing enzymes and transporters in order to degrade and excrete foreign chemicals or endogenous metabolites. This review aims to expand the perceived relevance of PXR and CAR beyond their established role as master xenosensors to disease-oriented areas, emphasizing their modulation by small molecules. Structural studies of these receptors have provided much-needed insight into the nature of their binding promiscuity and the important elements that lead to ligand binding. Reports of species- and isoform-selective activation highlight the need for further scrutiny when extrapolating from animal data to humans, as animal models are at the forefront of early drug discovery. Twit Text FOAVip Small-molecule modulators of PXR and CAR ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=26921498 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26921498 #FOAvip English Wikipedia <ref>{{Cite pmid|26921498}}</ref> Small-molecule modulators of PXR and CAR #MMPMID26921498 Chai SC; Cherian MT; Wang YM; Chen T Biochim Biophys Acta 2016[Sep]; 1859 (9): 1141-54 PMID26921498show ga Two nuclear receptors, the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR), participate in the xenobiotic detoxification system by regulating the expression of drug-metabolizing enzymes and transporters in order to degrade and excrete foreign chemicals or endogenous metabolites. This review aims to expand the perceived relevance of PXR and CAR beyond their established role as master xenosensors to disease-oriented areas, emphasizing their modulation by small molecules. Structural studies of these receptors have provided much-needed insight into the nature of their binding promiscuity and the important elements that lead to ligand binding. Reports of species- and isoform-selective activation highlight the need for further scrutiny when extrapolating from animal data to humans, as animal models are at the forefront of early drug discovery. äSmall-molecule modulators of PXR and CAR (epmc).pdf DeepDyve Pubget Overpricing