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10.1016/j.cell.2016.02.048

http://scihub22266oqcxt.onion/10.1016/j.cell.2016.02.048
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C4973889!4973889!26967286
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suck abstract from ncbi

pmid26967286      Cell 2016 ; 164 (6): 1198-211
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  • Hallmarks of Tissue-Resident Lymphocytes #MMPMID26967286
  • Fan X; Rudensky AY
  • Cell 2016[Mar]; 164 (6): 1198-211 PMID26967286show ga
  • Although they are classically viewed as continuously recirculating through the lymphoid organs and blood, lymphocytes also establish residency in non-lymphoid tissues, most prominently at barrier sites, including the mucosal surfaces and skin. These specialized tissue-resident lymphocyte subsets span the innate-adaptive continuum and include innate lymphoid cells (ILCs), unconventional T cells (e.g., NKT, MAIT, ?? T cells, and CD8??+IELs), and tissue-resident memory T (TRM) cells. Although these diverse cell types differ in the particulars of their biology, they nonetheless exhibit important shared features, including a role in the preservation of tissue integrity and function during homeostasis, infection, and non-infectious perturbations. In this Review, we discuss the hallmarks of tissue-resident innate, innate-like, and adaptive lymphocytes, as well as their potential functions in non-lymphoid organs.
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