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10.15252/embj.201593596 http://scihub22266oqcxt.onion/10.15252/embj.201593596 C4972138!4972138!26988033     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+J 2016 ; 35 (8): 866-80 Nephropedia Template TP {{tp|p=26988033|t=2016. USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin?1 |pdf=|usr=}}{{26988033}} gab.com Text USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin 1 JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=26988033 #FOAvip Autophagy, mediated by a number of autophagy?related (ATG) proteins, plays an important role in the bulk degradation of cellular constituents. Beclin?1 (also known as Atg6 in yeast) is a core protein essential for autophagic initiation and other biological processes. The activity of Beclin?1 is tightly regulated by multiple post?translational modifications, including ubiquitination, yet the molecular mechanism underpinning its reversible deubiquitination remains poorly defined. Here, we identified ubiquitin?specific protease 19 (USP19) as a positive regulator of autophagy, but a negative regulator of type I interferon (IFN) signaling. USP19 stabilizes Beclin?1 by removing the K11?linked ubiquitin chains of Beclin?1 at lysine 437. Moreover, we found that USP19 negatively regulates type I IFN signaling pathway, by blocking RIG?I?MAVS interaction in a Beclin?1?dependent manner. Depletion of either USP19 or Beclin?1 inhibits autophagic flux and promotes type I IFN signaling as well as cellular antiviral immunity. Our findings reveal novel dual functions of the USP19?Beclin?1 axis by balancing autophagy and the production of type I IFNs. Twit Text FOAVip USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin 1 ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=26988033 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26988033 #FOAvip English Wikipedia <ref>{{Cite pmid|26988033}}</ref> USP19 modulates autophagy and antiviral immune responses by deubiquitinating Beclin?1 #MMPMID26988033 Jin S; Tian S; Chen Y; Zhang C; Xie W; Xia X; Cui J; Wang R EMBO J 2016[Apr]; 35 (8): 866-80 PMID26988033show ga Autophagy, mediated by a number of autophagy?related (ATG) proteins, plays an important role in the bulk degradation of cellular constituents. Beclin?1 (also known as Atg6 in yeast) is a core protein essential for autophagic initiation and other biological processes. The activity of Beclin?1 is tightly regulated by multiple post?translational modifications, including ubiquitination, yet the molecular mechanism underpinning its reversible deubiquitination remains poorly defined. Here, we identified ubiquitin?specific protease 19 (USP19) as a positive regulator of autophagy, but a negative regulator of type I interferon (IFN) signaling. USP19 stabilizes Beclin?1 by removing the K11?linked ubiquitin chains of Beclin?1 at lysine 437. Moreover, we found that USP19 negatively regulates type I IFN signaling pathway, by blocking RIG?I?MAVS interaction in a Beclin?1?dependent manner. Depletion of either USP19 or Beclin?1 inhibits autophagic flux and promotes type I IFN signaling as well as cellular antiviral immunity. Our findings reveal novel dual functions of the USP19?Beclin?1 axis by balancing autophagy and the production of type I IFNs. äUSP19 modulates autophagy and antiviral immune responses by deubiquiti(epmc).pdf DeepDyve Pubget Overpricing