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10.15252/embj.201591459 http://scihub22266oqcxt.onion/10.15252/embj.201591459 C4972135!4972135 !26957522     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26957522 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+J 2016 ; 35 (8 ): 881-98 Nephropedia Template TP {{tp|p=26957522 |t=2016. The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6 |pdf=|usr=}}{{26957522 }} gab.com Text The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6 JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=26957522 #FOAvip Follicular T helper (Tfh) cells are key regulators of the germinal center reaction and long-term humoral immunity. Tfh cell differentiation requires the sustained expression of the transcriptional repressor Bcl6; however, its regulation in CD4(+)T cells is incompletely understood. Here, we report that the transcriptional coactivator Bob1, encoded by thePou2af1gene, promotes Bcl6 expression and Tfh cell development. We found that Bob1 together with the octamer transcription factors Oct1/Oct2 can directly bind to and transactivate theBcl6andBtlapromoters. Mixed bone marrow chimeras revealed that Bob1 is required for the expression of normal levels of Bcl6 andBTLA, thereby controlling the pool size and composition of the Tfh compartment in a T cell-intrinsic manner. Our data indicate that T cell-expressed Bob1 is directly involved in Tfh cell differentiation and required for mounting normal T cell-dependent B-cell responses. Twit Text FOAVip The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6 ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=26957522 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26957522 #FOAvip English Wikipedia <ref>{{Cite pmid|26957522 }}</ref> The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6 #MMPMID26957522 Stauss D ; Brunner C ; Berberich-Siebelt F ; Höpken UE ; Lipp M ; Müller G EMBO J 2016[Apr]; 35 (8 ): 881-98 PMID26957522 show ga Follicular T helper (Tfh) cells are key regulators of the germinal center reaction and long-term humoral immunity. Tfh cell differentiation requires the sustained expression of the transcriptional repressor Bcl6; however, its regulation in CD4(+)T cells is incompletely understood. Here, we report that the transcriptional coactivator Bob1, encoded by thePou2af1gene, promotes Bcl6 expression and Tfh cell development. We found that Bob1 together with the octamer transcription factors Oct1/Oct2 can directly bind to and transactivate theBcl6andBtlapromoters. Mixed bone marrow chimeras revealed that Bob1 is required for the expression of normal levels of Bcl6 andBTLA, thereby controlling the pool size and composition of the Tfh compartment in a T cell-intrinsic manner. Our data indicate that T cell-expressed Bob1 is directly involved in Tfh cell differentiation and required for mounting normal T cell-dependent B-cell responses. |Animals [MESH] |Binding Sites [MESH] |CD4-Positive T-Lymphocytes/immunology [MESH] |Cell Differentiation [MESH] |DNA-Binding Proteins/genetics/*metabolism [MESH] |Female [MESH] |Gene Expression Regulation [MESH] |Immunization [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Mice, Mutant Strains [MESH] |Promoter Regions, Genetic [MESH] |Proto-Oncogene Proteins c-bcl-6 [MESH] |Receptors, Immunologic/genetics/metabolism [MESH] |Receptors, Interleukin-21/genetics/metabolism [MESH] |Receptors, Interleukin-6/genetics/metabolism [MESH] |T-Lymphocytes, Helper-Inducer/*cytology/physiology [MESH]The transcriptional coactivator Bob1 promotes the development of folli(epmc).pdf DeepDyve Pubget Overpricing