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10.1080/23723556.2016.1159275 http://scihub22266oqcxt.onion/10.1080/23723556.2016.1159275 C4972111!4972111 !27652314     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27652314 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Mol+Cell+Oncol 2016 ; 3 (4 ): e1159275 Nephropedia Template TP {{tp|p=27652314 |t=2016. A new mechanism of regulation of p21 by the mTORC1/4E-BP1 pathway predicts clinical outcome of head and neck cancer |pdf=|usr=}}{{27652314 }} gab.com Text A new mechanism of regulation of p21 by the mTORC1/4E-BP1 pathway predicts clinical outcome of head and neck cancer JO: Mol Cell Oncol http://www.kidney.de/pget.php?&tw=1&pmid=27652314 #FOAvip We have identified a novel mechanism of regulation of the protein CDKN1A (also known as p21) by the serine/threonine kinase complex mammalian target of rapamycin complex 1 (mTORC1). Our results demonstrate that the mTORC1 substrate EIF4E-binding protein 1 (4E-BP1) in its non-phosphorylated state interacts with p21 and promotes p21 degradation. In addition, we demonstrate the prevalence of this mechanism in head and neck squamous cell carcinomas and show that it strongly and significantly associates with improved disease-specific survival, providing evidence for its clinical relevance. Twit Text FOAVip A new mechanism of regulation of p21 by the mTORC1/4E-BP1 pathway predicts clinical outcome of head and neck cancer ????Mol Cell Oncol http://www.kidney.de/pget.php?&tw=1&pmid=27652314 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27652314 #FOAvip English Wikipedia <ref>{{Cite pmid|27652314 }}</ref> A new mechanism of regulation of p21 by the mTORC1/4E-BP1 pathway predicts clinical outcome of head and neck cancer #MMPMID27652314 Llanos S ; García-Pedrero JM Mol Cell Oncol 2016[Jul]; 3 (4 ): e1159275 PMID27652314 show ga We have identified a novel mechanism of regulation of the protein CDKN1A (also known as p21) by the serine/threonine kinase complex mammalian target of rapamycin complex 1 (mTORC1). Our results demonstrate that the mTORC1 substrate EIF4E-binding protein 1 (4E-BP1) in its non-phosphorylated state interacts with p21 and promotes p21 degradation. In addition, we demonstrate the prevalence of this mechanism in head and neck squamous cell carcinomas and show that it strongly and significantly associates with improved disease-specific survival, providing evidence for its clinical relevance. ?A new mechanism of regulation of p21 by the mTORC1/4E-BP1 pathway pred(epmc).pdf DeepDyve Pubget Overpricing