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10.1080/23723556.2016.1182241

http://scihub22266oqcxt.onion/10.1080/23723556.2016.1182241
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C4972109!4972109!27652326
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suck abstract from ncbi


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pmid27652326      Mol+Cell+Oncol 2016 ; 3 (4): ä
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  • Vesicular trafficking regulators are new players in breast cancer progression: Role of TOM1L1 in ERBB2-dependent invasion #MMPMID27652326
  • Chevalier C; Roche S; Bénistant C
  • Mol Cell Oncol 2016[Jul]; 3 (4): ä PMID27652326show ga
  • ERBB2 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2) amplification is associated with invasive breast cancer. We discovered that TOM1L1 (target of myb1-like 1) and ERBB2 co-amplification defines a novel mechanism involved in breast cancer metastatic progression. Upregulation of the vesicular trafficking protein TOM1L1 enhances plasma membrane delivery of membrane-type 1 matrix metalloprotease (MT1-MMP) for efficient extracellular matrix degradation and tumor cell dissemination.
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