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10.1152/ajprenal.00649.2014 http://scihub22266oqcxt.onion/10.1152/ajprenal.00649.2014 C4971829!4971829 !25694485     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25694485 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Physiol+Renal+Physiol 2015 ; 308 (8 ): F910-22 Nephropedia Template TP {{tp|p=25694485 |t=2015. Aliskiren restores renal AQP2 expression during unilateral ureteral obstruction by inhibiting the inflammasome |pdf=|usr=}}{{25694485 }} gab.com Text Aliskiren restores renal AQP2 expression during unilateral ureteral obstruction by inhibiting the inflammasome JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25694485 #FOAvip Ureteral obstruction is associated with reduced expression of renal aquaporins (AQPs), urinary concentrating defects, and an enhanced inflammatory response, in which the renin-angiotensin system (RAS) may play an important role. We evaluated whether RAS blockade by a direct renin inhibitor, aliskiren, would prevent the decreased renal protein expression of AQPs in a unilateral ureteral obstruction (UUO) model and what potential mechanisms may be involved. UUO was performed for 3 days (3UUO) and 7 days (7UUO) in C57BL/6 mice with or without aliskiren injection. In 3UUO and 7UUO mice, aliskiren abolished the reduction of AQP2 protein expression but not AQP1, AQP3, and AQP4. mRNA levels of renal AQP2 and vasopressin type 2 receptor were decreased in obstructed kidneys of 7UUO mice, which were prevented by aliskiren treatment. Aliskiren treatment was also associated with a reduced inflammatory response in obstructed kidneys of UUO mice. Aliskiren significantly decreased mRNA levels of several proinflammatory factors, such as transforming growth factor-? and tumor necrosis factor-?, seen in obstructed kidneys of UUO mice. Interestingly, mRNA and protein levels of the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome components apoptosis-associated speck-like protein containing a caspase recruitment domain, caspase-1, and IL-1? were dramatically increased in obstructed kidneys of 7UUO mice, which were significantly suppressed by aliskiren. In primary cultured inner medullary collecting duct cells, IL-1? significantly decreased AQP2 expression. In conclusions, RAS blockade with the direct renin inhibitor aliskiren increased water channel AQP2 expression in obstructed kidneys of UUO mice, at least partially by preventing NLRP3 inflammasome activation in association with ureteral obstruction. Twit Text FOAVip Aliskiren restores renal AQP2 expression during unilateral ureteral obstruction by inhibiting the inflammasome ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25694485 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25694485 #FOAvip English Wikipedia <ref>{{Cite pmid|25694485 }}</ref> Aliskiren restores renal AQP2 expression during unilateral ureteral obstruction by inhibiting the inflammasome #MMPMID25694485 Wang W ; Luo R ; Lin Y ; Wang F ; Zheng P ; Levi M ; Yang T ; Li C Am J Physiol Renal Physiol 2015[Apr]; 308 (8 ): F910-22 PMID25694485 show ga Ureteral obstruction is associated with reduced expression of renal aquaporins (AQPs), urinary concentrating defects, and an enhanced inflammatory response, in which the renin-angiotensin system (RAS) may play an important role. We evaluated whether RAS blockade by a direct renin inhibitor, aliskiren, would prevent the decreased renal protein expression of AQPs in a unilateral ureteral obstruction (UUO) model and what potential mechanisms may be involved. UUO was performed for 3 days (3UUO) and 7 days (7UUO) in C57BL/6 mice with or without aliskiren injection. In 3UUO and 7UUO mice, aliskiren abolished the reduction of AQP2 protein expression but not AQP1, AQP3, and AQP4. mRNA levels of renal AQP2 and vasopressin type 2 receptor were decreased in obstructed kidneys of 7UUO mice, which were prevented by aliskiren treatment. Aliskiren treatment was also associated with a reduced inflammatory response in obstructed kidneys of UUO mice. Aliskiren significantly decreased mRNA levels of several proinflammatory factors, such as transforming growth factor-? and tumor necrosis factor-?, seen in obstructed kidneys of UUO mice. Interestingly, mRNA and protein levels of the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome components apoptosis-associated speck-like protein containing a caspase recruitment domain, caspase-1, and IL-1? were dramatically increased in obstructed kidneys of 7UUO mice, which were significantly suppressed by aliskiren. In primary cultured inner medullary collecting duct cells, IL-1? significantly decreased AQP2 expression. In conclusions, RAS blockade with the direct renin inhibitor aliskiren increased water channel AQP2 expression in obstructed kidneys of UUO mice, at least partially by preventing NLRP3 inflammasome activation in association with ureteral obstruction. |Amides/*pharmacology [MESH] |Angiotensin II Type 1 Receptor Blockers/pharmacology [MESH] |Angiotensin-Converting Enzyme Inhibitors/pharmacology [MESH] |Animals [MESH] |Aquaporin 2/*drug effects/genetics/metabolism [MESH] |Carrier Proteins/metabolism [MESH] |Cells, Cultured [MESH] |Cytoprotection [MESH] |Disease Models, Animal [MESH] |Fumarates/*pharmacology [MESH] |Inflammasomes/*antagonists & inhibitors/metabolism [MESH] |Inflammation Mediators/metabolism [MESH] |Kidney Diseases/etiology/genetics/metabolism/*prevention & control [MESH] |Kidney/*drug effects/metabolism [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |NLR Family, Pyrin Domain-Containing 3 Protein [MESH] |RNA, Messenger/metabolism [MESH] |Rats, Wistar [MESH] |Receptors, Cytoplasmic and Nuclear/metabolism [MESH] |Renin-Angiotensin System/drug effects [MESH] |Renin/antagonists & inhibitors/metabolism [MESH] |Time Factors [MESH] |Up-Regulation [MESH]Aliskiren restores renal AQP2 expression during unilateral ureteral ob(epmc).pdf DeepDyve Pubget Overpricing