Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/cas.12919 http://scihub22266oqcxt.onion/10.1111/cas.12919 C4970826!4970826!26920496     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Sci 2016 ; 107 (5): 590-600 Nephropedia Template TP {{tp|p=26920496|t=2016. Phase I study of a new cancer vaccine of ten mixed peptides for advanced cancer patients |pdf=|usr=}}{{26920496}} gab.com Text Phase I study of a new cancer vaccine of ten mixed peptides for advanced cancer patients JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=26920496 #FOAvip A phase I study of a new cancer vaccine (KRM?10), consisting of a mixture of 10 different short peptides, was conducted for patients with advanced gastrointestinal cancers. Primary or secondary endpoints included the dose?limiting toxicity (DLT), or safety and immune responses, respectively. Peptide?specific cytotoxic T lymphocytes (CTL) and immunoglobulin G (IgG), together with soluble inflammatory factors, were measured before and after vaccination. Twenty?one patients were vaccinated with KRM?10 at dose levels of 10 (n = 6), 20 (n = 8) or 30 mg (n = 7) of peptides every week for 6 weeks. No DLT were observed in the dose range evaluated. Common treatment?related adverse events were a grade 1 injection site reaction in 15 patients, and fever in three patients (grade 1 in two patients and grade 2 in one patient). CTL activity to at least one peptide at the time of the third and sixth vaccination increased in 2 and 3 of 6 (10 mg), 2 of 8 and 4 of 6 (20 mg), or 2 and 1 of 6 (30 mg) patients, respectively. IgG levels, at the third and sixth vaccination, were also increased in 1 and 1 of 6 (10 mg), 2 of 8 and 4 of 6 (20 mg), or 1 and 3 of 6 (30 mg) patients, respectively. The KRM?10 vaccine consisting of 20 mg of peptides was determined as the optimal dose for a coming phase II trial because of its safety, and also for demonstrating the most potent activity for augmenting the immune response of the three doses tested. This trial was registered at the UMIN Clinical Trials Registry as UMIN000008820. Twit Text FOAVip Phase I study of a new cancer vaccine of ten mixed peptides for advanced cancer patients ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=26920496 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26920496 #FOAvip English Wikipedia <ref>{{Cite pmid|26920496}}</ref> Phase I study of a new cancer vaccine of ten mixed peptides for advanced cancer patients #MMPMID26920496 Iwasa S; Yamada Y; Heike Y; Shoji H; Honma Y; Komatsu N; Matsueda S; Yamada A; Morita M; Yamaguchi R; Tanaka N; Kawahara A; Kage M; Shichijo S; Sasada T; Itoh K Cancer Sci 2016[May]; 107 (5): 590-600 PMID26920496show ga A phase I study of a new cancer vaccine (KRM?10), consisting of a mixture of 10 different short peptides, was conducted for patients with advanced gastrointestinal cancers. Primary or secondary endpoints included the dose?limiting toxicity (DLT), or safety and immune responses, respectively. Peptide?specific cytotoxic T lymphocytes (CTL) and immunoglobulin G (IgG), together with soluble inflammatory factors, were measured before and after vaccination. Twenty?one patients were vaccinated with KRM?10 at dose levels of 10 (n = 6), 20 (n = 8) or 30 mg (n = 7) of peptides every week for 6 weeks. No DLT were observed in the dose range evaluated. Common treatment?related adverse events were a grade 1 injection site reaction in 15 patients, and fever in three patients (grade 1 in two patients and grade 2 in one patient). CTL activity to at least one peptide at the time of the third and sixth vaccination increased in 2 and 3 of 6 (10 mg), 2 of 8 and 4 of 6 (20 mg), or 2 and 1 of 6 (30 mg) patients, respectively. IgG levels, at the third and sixth vaccination, were also increased in 1 and 1 of 6 (10 mg), 2 of 8 and 4 of 6 (20 mg), or 1 and 3 of 6 (30 mg) patients, respectively. The KRM?10 vaccine consisting of 20 mg of peptides was determined as the optimal dose for a coming phase II trial because of its safety, and also for demonstrating the most potent activity for augmenting the immune response of the three doses tested. This trial was registered at the UMIN Clinical Trials Registry as UMIN000008820. äPhase I study of a new cancer vaccine of ten mixed peptides for advanc(epmc).pdf DeepDyve Pubget Overpricing