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10.1016/j.cell.2016.05.025 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.05.025 C4970759!4970759!27293191     free     free     free       Cell 2016 ; 166 (2): 358-68 Nephropedia Template TP {{tp|p=27293191|t=2016. Enhancer control of transcriptional bursting |pdf=|usr=}}{{27293191}} gab.com Text Enhancer control of transcriptional bursting JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=27293191 #FOAvip Transcription is episodic, consisting of a series of discontinuous bursts. Using live imaging methods and quantitative analysis, we examine transcriptional bursting in living Drosophila embryos. Different developmental enhancers positioned downstream of synthetic reporter genes produce transcriptional bursts with similar amplitudes and duration, but generate very different bursting frequencies, with strong enhancers producing more bursts than weak enhancers. Insertion of an insulator reduces the number of bursts and the corresponding level of gene expression, suggesting that enhancer regulation of bursting frequency is a key parameter of gene control in development. We also show that linked reporter genes exhibit coordinated bursting profiles when regulated by a shared enhancer, challenging conventional models of enhancer-promoter looping. Twit Text FOAVip Enhancer control of transcriptional bursting ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=27293191 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27293191 #FOAvip English Wikipedia <ref>{{Cite pmid|27293191}}</ref> Enhancer control of transcriptional bursting #MMPMID27293191 Fukaya T; Lim B; Levine M Cell 2016[Jul]; 166 (2): 358-68 PMID27293191show ga Transcription is episodic, consisting of a series of discontinuous bursts. Using live imaging methods and quantitative analysis, we examine transcriptional bursting in living Drosophila embryos. Different developmental enhancers positioned downstream of synthetic reporter genes produce transcriptional bursts with similar amplitudes and duration, but generate very different bursting frequencies, with strong enhancers producing more bursts than weak enhancers. Insertion of an insulator reduces the number of bursts and the corresponding level of gene expression, suggesting that enhancer regulation of bursting frequency is a key parameter of gene control in development. We also show that linked reporter genes exhibit coordinated bursting profiles when regulated by a shared enhancer, challenging conventional models of enhancer-promoter looping. äEnhancer control of transcriptional bursting (epmc).pdf DeepDyve Pubget Overpricing