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10.1016/j.gene.2016.06.031 http://scihub22266oqcxt.onion/10.1016/j.gene.2016.06.031 C4969162!4969162!27320729     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Gene 2016 ; 590 (1): 128-41 Nephropedia Template TP {{tp|p=27320729|t=2016. POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologies |pdf=|usr=}}{{27320729}} gab.com Text POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologies JO: Gene http://www.kidney.de/pget.php?&tw=1&pmid=27320729 #FOAvip The evolutionarily conserved human polymerase delta (POLD1) gene encodes the large p125 subunit which provides the essential catalytic activities of polymerase ? (Pol?), mediated by 5??3? DNA polymerase and 3??5? exonuclease moieties. POLD1 associates with three smaller subunits (POLD2, POLD3, POLD4), which together with Replication Factor C and Proliferating Nuclear Cell Antigen constitute the polymerase holoenzyme. Pol? function is essential for replication, with a primary role as the replicase for the lagging strand. Pol? also has an important proofreading ability conferred by the exonuclease activity, which is critical for ensuring replicative fidelity, but also serves to repair DNA lesions arising as a result of exposure to mutagens. Pol? has been shown to be important for multiple forms of DNA repair, including nucleotide excision repair, double strand break repair, base excision repair, and mismatch repair. A growing number of studies in the past decade have linked germline and sporadic mutations in POLD1 and the other subunits of Pol? with human pathologies. Mutations in Pol? in mice and humans lead to genomic instability, mutator phenotype and tumorigenesis. The advent of genome sequencing techniques has identified damaging mutations in the proofreading domain of POLD1 as the underlying cause of some inherited cancers, and suggested that mutations in POLD1 may influence therapeutic management. In addition, mutations in POLD1 have been identified in the developmental disorders of mandibular hypoplasia, deafness, progeroid features and lipodystrophy and atypical Werner syndrome, while changes in expression or activity of POLD1 have been linked to senescence and aging. Intriguingly, some recent evidence suggests that POLD1 function may also be altered in diabetes. We provide an overview of critical Pol? activities in the context of these pathologic conditions. Twit Text FOAVip POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologies ????Gene http://www.kidney.de/pget.php?&tw=1&pmid=27320729 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27320729 #FOAvip English Wikipedia <ref>{{Cite pmid|27320729}}</ref> POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologies #MMPMID27320729 Nicolas E; Golemis EA; Arora S Gene 2016[Sep]; 590 (1): 128-41 PMID27320729show ga The evolutionarily conserved human polymerase delta (POLD1) gene encodes the large p125 subunit which provides the essential catalytic activities of polymerase ? (Pol?), mediated by 5??3? DNA polymerase and 3??5? exonuclease moieties. POLD1 associates with three smaller subunits (POLD2, POLD3, POLD4), which together with Replication Factor C and Proliferating Nuclear Cell Antigen constitute the polymerase holoenzyme. Pol? function is essential for replication, with a primary role as the replicase for the lagging strand. Pol? also has an important proofreading ability conferred by the exonuclease activity, which is critical for ensuring replicative fidelity, but also serves to repair DNA lesions arising as a result of exposure to mutagens. Pol? has been shown to be important for multiple forms of DNA repair, including nucleotide excision repair, double strand break repair, base excision repair, and mismatch repair. A growing number of studies in the past decade have linked germline and sporadic mutations in POLD1 and the other subunits of Pol? with human pathologies. Mutations in Pol? in mice and humans lead to genomic instability, mutator phenotype and tumorigenesis. The advent of genome sequencing techniques has identified damaging mutations in the proofreading domain of POLD1 as the underlying cause of some inherited cancers, and suggested that mutations in POLD1 may influence therapeutic management. In addition, mutations in POLD1 have been identified in the developmental disorders of mandibular hypoplasia, deafness, progeroid features and lipodystrophy and atypical Werner syndrome, while changes in expression or activity of POLD1 have been linked to senescence and aging. Intriguingly, some recent evidence suggests that POLD1 function may also be altered in diabetes. We provide an overview of critical Pol? activities in the context of these pathologic conditions. äPOLD1: Central mediator of DNA replication and repair, and implication(epmc).pdf DeepDyve Pubget Overpricing