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10.1080/15384101.2016.1189042

http://scihub22266oqcxt.onion/10.1080/15384101.2016.1189042
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C4968954!4968954!27246297
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suck abstract from ncbi


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pmid27246297      Cell+Cycle 2016 ; 15 (15): 1956-60
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  • Genetic insights into Map3k-dependent proliferative expansion of T cells #MMPMID27246297
  • Suddason T; Gallagher E
  • Cell Cycle 2016[]; 15 (15): 1956-60 PMID27246297show ga
  • Mapks are important regulators of T cell proliferative expansion and cell cycle progression. Detailed genetic analysis of unconventional iNKT cells in both Map3k1?KD and LckCre/+Map3k1f/f mice demonstrated that Mekk1 (encoded by Map3k1) signaling activates Mapks to regulate Cdkn1b (encoding p27Kip1) expression and p27Kip1-dependent proliferative expansion in response to antigen. Mekk1 signaling and activation of E3 ubiquitin ligase Itch, by a phosphorylation-dependent conformational change, is also an important regulatory mechanism for the control of T helper cell cytokine production. Cdkn1b expression is regulated by Mekk1-dependent signaling in differentiated Th17 cells. Mekk1 is one of the 19 Ste11-like Map3ks, and Mekk1 signaling regulates iNKT cell proliferative expansion in response to glycolipid antigens and T cell homeostasis in the liver. Tak1 (encoded by Map3k7), a related Map3k to Mekk1, similarly regulates the proliferative expansion and homeostasis of T cells in the liver, and this illustrates the importance of multiple Map3ks for mammalian Mapk signaling.
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