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10.1016/j.immuni.2016.06.023 http://scihub22266oqcxt.onion/10.1016/j.immuni.2016.06.023 C4968938!4968938 !27438768     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27438768 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunity 2016 ; 45 (1 ): 94-105 Nephropedia Template TP {{tp|p=27438768 |t=2016. Ubiquitination of Innate Immune Regulator TRAF3 Orchestrates Expulsion of Intracellular Bacteria by Exocyst Complex |pdf=|usr=}}{{27438768 }} gab.com Text Ubiquitination of Innate Immune Regulator TRAF3 Orchestrates Expulsion of Intracellular Bacteria by Exocyst Complex JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=27438768 #FOAvip Although the intracellular trafficking system is integral to most physiologic activities, its role in mediating immune responses to infection has remained elusive. Here, we report that infected bladder epithelial cells (BECs) mobilized the exocyst complex, a powerful exporter of subcellular vesicles, to rapidly expel intracellular bacteria back for clearance. Toll-like receptor (TLR) 4 signals emanating from bacteria-containing vesicles (BCVs) were found to trigger K33-linked polyubiquitination of TRAF3 at Lys168, which was then detected by RalGDS, a guanine nucleotide exchange factor (GEF) that precipitated the assembly of the exocyst complex. Although this distinct modification of TRAF3 served to connect innate immune signaling to the cellular trafficking apparatus, it crucially ensured temporal and spatial accuracy in determining which among the many subcellular vesicles was recognized and selected for expulsion in response to innate immune signaling. Twit Text FOAVip Ubiquitination of Innate Immune Regulator TRAF3 Orchestrates Expulsion of Intracellular Bacteria by Exocyst Complex ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=27438768 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27438768 #FOAvip English Wikipedia <ref>{{Cite pmid|27438768 }}</ref> Ubiquitination of Innate Immune Regulator TRAF3 Orchestrates Expulsion of Intracellular Bacteria by Exocyst Complex #MMPMID27438768 Miao Y ; Wu J ; Abraham SN Immunity 2016[Jul]; 45 (1 ): 94-105 PMID27438768 show ga Although the intracellular trafficking system is integral to most physiologic activities, its role in mediating immune responses to infection has remained elusive. Here, we report that infected bladder epithelial cells (BECs) mobilized the exocyst complex, a powerful exporter of subcellular vesicles, to rapidly expel intracellular bacteria back for clearance. Toll-like receptor (TLR) 4 signals emanating from bacteria-containing vesicles (BCVs) were found to trigger K33-linked polyubiquitination of TRAF3 at Lys168, which was then detected by RalGDS, a guanine nucleotide exchange factor (GEF) that precipitated the assembly of the exocyst complex. Although this distinct modification of TRAF3 served to connect innate immune signaling to the cellular trafficking apparatus, it crucially ensured temporal and spatial accuracy in determining which among the many subcellular vesicles was recognized and selected for expulsion in response to innate immune signaling. |*Immunity, Innate [MESH] |Animals [MESH] |Cells, Cultured [MESH] |Escherichia coli/genetics/*immunology [MESH] |Exocytosis [MESH] |Female [MESH] |Humans [MESH] |Intracellular Space [MESH] |Mice [MESH] |Mice, Inbred C3H [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |RNA, Small Interfering/genetics [MESH] |Signal Transduction [MESH] |TNF Receptor-Associated Factor 3/genetics/*metabolism [MESH] |Toll-Like Receptor 4/genetics [MESH] |Transport Vesicles/*metabolism [MESH] |Ubiquitination [MESH] |Urinary Bladder/microbiology/*pathology [MESH] |Urinary Tract Infections/*immunology [MESH] |Urothelium/*immunology/microbiology [MESH]Ubiquitination of Innate Immune Regulator TRAF3 Orchestrates Expulsion(epmc).pdf DeepDyve Pubget Overpricing