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10.1080/15548627.2016.1187366 http://scihub22266oqcxt.onion/10.1080/15548627.2016.1187366 C4968231!4968231!27245739     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Autophagy 2016 ; 12 (8): 1425-8 Nephropedia Template TP {{tp|p=27245739|t=2016. Autophagy promotes ferroptosis by degradation of ferritin |pdf=|usr=}}{{27245739}} gab.com Text Autophagy promotes ferroptosis by degradation of ferritin JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=27245739 #FOAvip Macroautophagy/autophagy is an evolutionarily conserved degradation pathway that maintains homeostasis. Ferroptosis, a novel form of regulated cell death, is characterized by a production of reactive oxygen species from accumulated iron and lipid peroxidation. However, the relationship between autophagy and ferroptosis at the genetic level remains unclear. Here, we demonstrated that autophagy contributes to ferroptosis by degradation of ferritin in fibroblasts and cancer cells. Knockout or knockdown of Atg5 (autophagy-related 5) and Atg7 limited erastin-induced ferroptosis with decreased intracellular ferrous iron levels, and lipid peroxidation. Remarkably, NCOA4 (nuclear receptor coactivator 4) was a selective cargo receptor for the selective autophagic turnover of ferritin (namely ferritinophagy) in ferroptosis. Consistently, genetic inhibition of NCOA4 inhibited ferritin degradation and suppressed ferroptosis. In contrast, overexpression of NCOA4 increased ferritin degradation and promoted ferroptosis. These findings provide novel insight into the interplay between autophagy and regulated cell death. Twit Text FOAVip Autophagy promotes ferroptosis by degradation of ferritin ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=27245739 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27245739 #FOAvip English Wikipedia <ref>{{Cite pmid|27245739}}</ref> Autophagy promotes ferroptosis by degradation of ferritin #MMPMID27245739 Hou W; Xie Y; Song X; Sun X; Lotze MT; Zeh HJ; Kang R; Tang D Autophagy 2016[Aug]; 12 (8): 1425-8 PMID27245739show ga Macroautophagy/autophagy is an evolutionarily conserved degradation pathway that maintains homeostasis. Ferroptosis, a novel form of regulated cell death, is characterized by a production of reactive oxygen species from accumulated iron and lipid peroxidation. However, the relationship between autophagy and ferroptosis at the genetic level remains unclear. Here, we demonstrated that autophagy contributes to ferroptosis by degradation of ferritin in fibroblasts and cancer cells. Knockout or knockdown of Atg5 (autophagy-related 5) and Atg7 limited erastin-induced ferroptosis with decreased intracellular ferrous iron levels, and lipid peroxidation. Remarkably, NCOA4 (nuclear receptor coactivator 4) was a selective cargo receptor for the selective autophagic turnover of ferritin (namely ferritinophagy) in ferroptosis. Consistently, genetic inhibition of NCOA4 inhibited ferritin degradation and suppressed ferroptosis. In contrast, overexpression of NCOA4 increased ferritin degradation and promoted ferroptosis. These findings provide novel insight into the interplay between autophagy and regulated cell death. äAutophagy promotes ferroptosis by degradation of ferritin (epmc).pdf DeepDyve Pubget Overpricing