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10.1080/15548627.2016.1179405 http://scihub22266oqcxt.onion/10.1080/15548627.2016.1179405 C4968228!4968228!27171064     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Autophagy 2016 ; 12 (8): 1240-58 Nephropedia Template TP {{tp|p=27171064|t=2016. TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages |pdf=|usr=}}{{27171064}} gab.com Text TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=27171064 #FOAvip The activation of transcription factors is critical to ensure an effective defense against pathogens. In this study we identify a critical and complementary role of the transcription factors TFEB and TFE3 in innate immune response. By using a combination of chromatin immunoprecipitation, CRISPR-Cas9-mediated genome-editing technology, and in vivo models, we determined that TFEB and TFE3 collaborate with each other in activated macrophages and microglia to promote efficient autophagy induction, increased lysosomal biogenesis, and transcriptional upregulation of numerous proinflammatory cytokines. Furthermore, secretion of key mediators of the inflammatory response (CSF2, IL1B, IL2, and IL27), macrophage differentiation (CSF1), and macrophage infiltration and migration to sites of inflammation (CCL2) was significantly reduced in TFEB and TFE3 deficient cells. These new insights provide us with a deeper understanding of the transcriptional regulation of the innate immune response. Twit Text FOAVip TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=27171064 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27171064 #FOAvip English Wikipedia <ref>{{Cite pmid|27171064}}</ref> TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages #MMPMID27171064 Pastore N; Brady OA; Diab HI; Martina JA; Sun L; Huynh T; Lim JA; Zare H; Raben N; Ballabio A; Puertollano R Autophagy 2016[Aug]; 12 (8): 1240-58 PMID27171064show ga The activation of transcription factors is critical to ensure an effective defense against pathogens. In this study we identify a critical and complementary role of the transcription factors TFEB and TFE3 in innate immune response. By using a combination of chromatin immunoprecipitation, CRISPR-Cas9-mediated genome-editing technology, and in vivo models, we determined that TFEB and TFE3 collaborate with each other in activated macrophages and microglia to promote efficient autophagy induction, increased lysosomal biogenesis, and transcriptional upregulation of numerous proinflammatory cytokines. Furthermore, secretion of key mediators of the inflammatory response (CSF2, IL1B, IL2, and IL27), macrophage differentiation (CSF1), and macrophage infiltration and migration to sites of inflammation (CCL2) was significantly reduced in TFEB and TFE3 deficient cells. These new insights provide us with a deeper understanding of the transcriptional regulation of the innate immune response. äTFEB and TFE3 cooperate in the regulation of the innate immune respons(epmc).pdf DeepDyve Pubget Overpricing