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10.1080/19420862.2016.1178436 http://scihub22266oqcxt.onion/10.1080/19420862.2016.1178436 C4968098!4968098!27104806     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       MAbs 2016 ; 8 (5): 848-53 Nephropedia Template TP {{tp|p=27104806|t=2016. Tissue expression profile of human neonatal Fc receptor (FcRn) in Tg32 transgenic mice |pdf=|usr=}}{{27104806}} gab.com Text Tissue expression profile of human neonatal Fc receptor (FcRn) in Tg32 transgenic mice JO: MAbs http://www.kidney.de/pget.php?&tw=1&pmid=27104806 #FOAvip The neonatal Fc receptor (FcRn) is a homeostatic receptor responsible for prolonging immunoglobulin G (IgG) half-life by protecting it from lysosomal degradation and recycling it to systemic circulation. Tissue-specific FcRn expression is a critical parameter in physiologically-based pharmacokinetic (PBPK) modeling for translational pharmacokinetics of Fc-containing biotherapeutics. Using online peptide immuno-affinity chromatography coupled with high resolution mass spectrometry, we established a quantitative FcRn tissue protein expression profile in human FcRn (hFcRn) transgenic mice, Tg32 homozygous and hemizygous strains. The concentration of hFcRn across 14 tissues ranged from 3.5 to 111.2 pmole per gram of tissue. Our hFcRn quantification data from Tg32 mice will enable a more refined PBPK model to improve the accuracy of human PK predictions for Fc-containing biotherapeutics. Twit Text FOAVip Tissue expression profile of human neonatal Fc receptor (FcRn) in Tg32 transgenic mice ????MAbs http://www.kidney.de/pget.php?&tw=1&pmid=27104806 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27104806 #FOAvip English Wikipedia <ref>{{Cite pmid|27104806}}</ref> Tissue expression profile of human neonatal Fc receptor (FcRn) in Tg32 transgenic mice #MMPMID27104806 Fan YY; Avery LB; Wang M; O'Hara DM; Leung S; Neubert H MAbs 2016[Jul]; 8 (5): 848-53 PMID27104806show ga The neonatal Fc receptor (FcRn) is a homeostatic receptor responsible for prolonging immunoglobulin G (IgG) half-life by protecting it from lysosomal degradation and recycling it to systemic circulation. Tissue-specific FcRn expression is a critical parameter in physiologically-based pharmacokinetic (PBPK) modeling for translational pharmacokinetics of Fc-containing biotherapeutics. Using online peptide immuno-affinity chromatography coupled with high resolution mass spectrometry, we established a quantitative FcRn tissue protein expression profile in human FcRn (hFcRn) transgenic mice, Tg32 homozygous and hemizygous strains. The concentration of hFcRn across 14 tissues ranged from 3.5 to 111.2 pmole per gram of tissue. Our hFcRn quantification data from Tg32 mice will enable a more refined PBPK model to improve the accuracy of human PK predictions for Fc-containing biotherapeutics. äTissue expression profile of human neonatal Fc receptor (FcRn) in Tg32(epmc).pdf DeepDyve Pubget Overpricing