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10.3109/10409238.2016.1172554 http://scihub22266oqcxt.onion/10.3109/10409238.2016.1172554 C4968084!4968084!27098648     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Crit+Rev+Biochem+Mol+Biol 2015 ; 51 (4): 268-81 Nephropedia Template TP {{tp|p=27098648|t=2015. The Immunoproteasome in Oxidative Stress, Aging, and Disease |pdf=|usr=}}{{27098648}} gab.com Text The Immunoproteasome in Oxidative Stress, Aging, and Disease JO: Crit Rev Biochem Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=27098648 #FOAvip The Immunoproteasome has traditionally been viewed primarily for its role in peptide production for antigen presentation by the Major Histocompatibility Complex (MHC), which is critical for immunity. However, recent research has shown that the Immunoproteasome is also very important for the clearance of oxidatively damaged proteins in homeostasis, and especially during stress and disease. The importance of the Immunoproteasome in protein degradation has become more evident as diseases characterized by protein aggregates have also been linked to deficiencies of the Immunoproteasome. Additionally, there are now diseases defined by mutations or polymorphisms within Immunoproteasome-specific subunit genes, further suggesting its crucial role in cytokine signaling and protein homeostasis (or ?proteostasis?). The purpose of this review is to highlight our growing understanding of the importance of the Immunoproteasome in the management of protein quality control, and the detrimental impact of its dysregulation during disease and aging. Twit Text FOAVip The Immunoproteasome in Oxidative Stress, Aging, and Disease ????Crit Rev Biochem Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=27098648 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27098648 #FOAvip English Wikipedia <ref>{{Cite pmid|27098648}}</ref> The Immunoproteasome in Oxidative Stress, Aging, and Disease #MMPMID27098648 Johnston-Carey HK; Pomatto LC; Davies KJA Crit Rev Biochem Mol Biol 2015[Jul]; 51 (4): 268-81 PMID27098648show ga The Immunoproteasome has traditionally been viewed primarily for its role in peptide production for antigen presentation by the Major Histocompatibility Complex (MHC), which is critical for immunity. However, recent research has shown that the Immunoproteasome is also very important for the clearance of oxidatively damaged proteins in homeostasis, and especially during stress and disease. The importance of the Immunoproteasome in protein degradation has become more evident as diseases characterized by protein aggregates have also been linked to deficiencies of the Immunoproteasome. Additionally, there are now diseases defined by mutations or polymorphisms within Immunoproteasome-specific subunit genes, further suggesting its crucial role in cytokine signaling and protein homeostasis (or ?proteostasis?). The purpose of this review is to highlight our growing understanding of the importance of the Immunoproteasome in the management of protein quality control, and the detrimental impact of its dysregulation during disease and aging. äThe Immunoproteasome in Oxidative Stress, Aging, and Disease (epmc).pdf DeepDyve Pubget Overpricing