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10.1152/ajprenal.00184.2016 http://scihub22266oqcxt.onion/10.1152/ajprenal.00184.2016 C4967158!4967158!27097894     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Renal+Physiol 2016 ; 311 (1): F46-51 Nephropedia Template TP {{tp|p=27097894|t=2016. The podocyte as a direct target for treatment of glomerular disease?|pdf=|usr=}}{{27097894}} gab.com Text The podocyte as a direct target for treatment of glomerular disease JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27097894 #FOAvip The Centers for Disease Control and Prevention estimates more than 10% of adults in the United States, over 20 million Americans, have chronic kidney disease (CKD). A failure to maintain the glomerular filtration barrier directly contributes to the onset of CKD. The visceral epithelial cells, podocytes, are integral to the maintenance of this renal filtration barrier. Direct podocyte injury contributes to the onset and progression of glomerular diseases such as minimal change disease (MCD), focal segmental glomerular sclerosis (FSGS), diabetic nephropathy, and HIV-associated nephropathy (HIVAN). Since podocytes are terminally differentiated with minimal capacity to self-replicate, they are extremely sensitive to cellular injury. In the past two decades, our understanding of the mechanism(s) by which podocyte injury occurs has greatly expanded. With this newfound knowledge, therapeutic strategies have shifted to identifying targets directed specifically at the podocyte. Although the systemic effects of these agents are important, their direct effect on the podocyte proves to be essential in ameliorating glomerular disease. In this review, we highlight the mechanisms by which these agents directly target the podocyte independent of its systemic effects. Twit Text FOAVip The podocyte as a direct target for treatment of glomerular disease ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27097894 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27097894 #FOAvip English Wikipedia <ref>{{Cite pmid|27097894}}</ref> The podocyte as a direct target for treatment of glomerular disease? #MMPMID27097894 Mallipattu SK; He JC Am J Physiol Renal Physiol 2016[Jul]; 311 (1): F46-51 PMID27097894show ga The Centers for Disease Control and Prevention estimates more than 10% of adults in the United States, over 20 million Americans, have chronic kidney disease (CKD). A failure to maintain the glomerular filtration barrier directly contributes to the onset of CKD. The visceral epithelial cells, podocytes, are integral to the maintenance of this renal filtration barrier. Direct podocyte injury contributes to the onset and progression of glomerular diseases such as minimal change disease (MCD), focal segmental glomerular sclerosis (FSGS), diabetic nephropathy, and HIV-associated nephropathy (HIVAN). Since podocytes are terminally differentiated with minimal capacity to self-replicate, they are extremely sensitive to cellular injury. In the past two decades, our understanding of the mechanism(s) by which podocyte injury occurs has greatly expanded. With this newfound knowledge, therapeutic strategies have shifted to identifying targets directed specifically at the podocyte. Although the systemic effects of these agents are important, their direct effect on the podocyte proves to be essential in ameliorating glomerular disease. In this review, we highlight the mechanisms by which these agents directly target the podocyte independent of its systemic effects. äThe podocyte as a direct target for treatment of glomerular disease?(epmc).pdf DeepDyve Pubget Overpricing