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10.1152/ajpcell.00319.2015 http://scihub22266oqcxt.onion/10.1152/ajpcell.00319.2015 C4967134!4967134!27122161     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Cell+Physiol 2016 ; 311 (1): C67-80 Nephropedia Template TP {{tp|p=27122161|t=2016. The mitochondrial Ca2+ uniporter: regulation by auxiliary subunits and signal transduction pathways |pdf=|usr=}}{{27122161}} gab.com Text The mitochondrial Ca2+ uniporter: regulation by auxiliary subunits and signal transduction pathways JO: Am J Physiol Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27122161 #FOAvip Mitochondrial Ca2+ homeostasis, the Ca2+ influx-efflux balance, is responsible for the control of numerous cellular functions, including energy metabolism, generation of reactive oxygen species, spatiotemporal dynamics of Ca2+ signaling, and cell growth and death. Recent discovery of the molecular identity of the mitochondrial Ca2+ uniporter (MCU) provides new possibilities for application of genetic approaches to study the mitochondrial Ca2+ influx mechanism in various cell types and tissues. In addition, the subsequent discovery of various auxiliary subunits associated with MCU suggests that mitochondrial Ca2+ uptake is not solely regulated by a single protein (MCU), but likely by a macromolecular protein complex, referred to as the MCU-protein complex (mtCUC). Moreover, recent reports have shown the potential role of MCU posttranslational modifications in the regulation of mitochondrial Ca2+ uptake through mtCUC. These observations indicate that mtCUCs form a local signaling complex at the inner mitochondrial membrane that could significantly regulate mitochondrial Ca2+ handling, as well as numerous mitochondrial and cellular functions. In this review we discuss the current literature on mitochondrial Ca2+ uptake mechanisms, with a particular focus on the structure and function of mtCUC, as well as its regulation by signal transduction pathways, highlighting current controversies and discrepancies. Twit Text FOAVip The mitochondrial Ca2+ uniporter: regulation by auxiliary subunits and signal transduction pathways ????Am J Physiol Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27122161 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27122161 #FOAvip English Wikipedia <ref>{{Cite pmid|27122161}}</ref> The mitochondrial Ca2+ uniporter: regulation by auxiliary subunits and signal transduction pathways #MMPMID27122161 Jhun BS; Mishra J; Monaco S; Fu D; Jiang W; Sheu SS; O-Uchi J Am J Physiol Cell Physiol 2016[Jul]; 311 (1): C67-80 PMID27122161show ga Mitochondrial Ca2+ homeostasis, the Ca2+ influx-efflux balance, is responsible for the control of numerous cellular functions, including energy metabolism, generation of reactive oxygen species, spatiotemporal dynamics of Ca2+ signaling, and cell growth and death. Recent discovery of the molecular identity of the mitochondrial Ca2+ uniporter (MCU) provides new possibilities for application of genetic approaches to study the mitochondrial Ca2+ influx mechanism in various cell types and tissues. In addition, the subsequent discovery of various auxiliary subunits associated with MCU suggests that mitochondrial Ca2+ uptake is not solely regulated by a single protein (MCU), but likely by a macromolecular protein complex, referred to as the MCU-protein complex (mtCUC). Moreover, recent reports have shown the potential role of MCU posttranslational modifications in the regulation of mitochondrial Ca2+ uptake through mtCUC. These observations indicate that mtCUCs form a local signaling complex at the inner mitochondrial membrane that could significantly regulate mitochondrial Ca2+ handling, as well as numerous mitochondrial and cellular functions. In this review we discuss the current literature on mitochondrial Ca2+ uptake mechanisms, with a particular focus on the structure and function of mtCUC, as well as its regulation by signal transduction pathways, highlighting current controversies and discrepancies. äThe mitochondrial Ca2+ uniporter: regulation by auxiliary subunits and(epmc).pdf DeepDyve Pubget Overpricing