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10.1152/ajpcell.00319.2015 http://scihub22266oqcxt.onion/10.1152/ajpcell.00319.2015 C4967134!4967134 !27122161     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27122161 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Physiol+Cell+Physiol 2016 ; 311 (1 ): C67-80 Nephropedia Template TP {{tp|p=27122161 |t=2016. The mitochondrial Ca2+ uniporter: regulation by auxiliary subunits and signal transduction pathways |pdf=|usr=}}{{27122161 }} gab.com Text The mitochondrial Ca2+ uniporter: regulation by auxiliary subunits and signal transduction pathways JO: Am J Physiol Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27122161 #FOAvip Mitochondrial Ca(2+) homeostasis, the Ca(2+) influx-efflux balance, is responsible for the control of numerous cellular functions, including energy metabolism, generation of reactive oxygen species, spatiotemporal dynamics of Ca(2+) signaling, and cell growth and death. Recent discovery of the molecular identity of the mitochondrial Ca(2+) uniporter (MCU) provides new possibilities for application of genetic approaches to study the mitochondrial Ca(2+) influx mechanism in various cell types and tissues. In addition, the subsequent discovery of various auxiliary subunits associated with MCU suggests that mitochondrial Ca(2+) uptake is not solely regulated by a single protein (MCU), but likely by a macromolecular protein complex, referred to as the MCU-protein complex (mtCUC). Moreover, recent reports have shown the potential role of MCU posttranslational modifications in the regulation of mitochondrial Ca(2+) uptake through mtCUC. These observations indicate that mtCUCs form a local signaling complex at the inner mitochondrial membrane that could significantly regulate mitochondrial Ca(2+) handling, as well as numerous mitochondrial and cellular functions. In this review we discuss the current literature on mitochondrial Ca(2+) uptake mechanisms, with a particular focus on the structure and function of mtCUC, as well as its regulation by signal transduction pathways, highlighting current controversies and discrepancies. Twit Text FOAVip The mitochondrial Ca2+ uniporter: regulation by auxiliary subunits and signal transduction pathways ????Am J Physiol Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27122161 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27122161 #FOAvip English Wikipedia <ref>{{Cite pmid|27122161 }}</ref> The mitochondrial Ca2+ uniporter: regulation by auxiliary subunits and signal transduction pathways #MMPMID27122161 Jhun BS ; Mishra J ; Monaco S ; Fu D ; Jiang W ; Sheu SS ; O-Uchi J Am J Physiol Cell Physiol 2016[Jul]; 311 (1 ): C67-80 PMID27122161 show ga Mitochondrial Ca(2+) homeostasis, the Ca(2+) influx-efflux balance, is responsible for the control of numerous cellular functions, including energy metabolism, generation of reactive oxygen species, spatiotemporal dynamics of Ca(2+) signaling, and cell growth and death. Recent discovery of the molecular identity of the mitochondrial Ca(2+) uniporter (MCU) provides new possibilities for application of genetic approaches to study the mitochondrial Ca(2+) influx mechanism in various cell types and tissues. In addition, the subsequent discovery of various auxiliary subunits associated with MCU suggests that mitochondrial Ca(2+) uptake is not solely regulated by a single protein (MCU), but likely by a macromolecular protein complex, referred to as the MCU-protein complex (mtCUC). Moreover, recent reports have shown the potential role of MCU posttranslational modifications in the regulation of mitochondrial Ca(2+) uptake through mtCUC. These observations indicate that mtCUCs form a local signaling complex at the inner mitochondrial membrane that could significantly regulate mitochondrial Ca(2+) handling, as well as numerous mitochondrial and cellular functions. In this review we discuss the current literature on mitochondrial Ca(2+) uptake mechanisms, with a particular focus on the structure and function of mtCUC, as well as its regulation by signal transduction pathways, highlighting current controversies and discrepancies. |*Calcium Signaling [MESH] |Animals [MESH] |Calcium Channels/chemistry/genetics/*metabolism [MESH] |Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism [MESH] |Homeostasis [MESH] |Humans [MESH] |Ion Channel Gating [MESH] |Mitochondria/*metabolism [MESH] |Mitochondrial Membranes/*metabolism [MESH] |Phosphorylation [MESH] |Protein Processing, Post-Translational [MESH] |Protein Structure, Quaternary [MESH] |Protein Subunits [MESH] |RNA Processing, Post-Transcriptional [MESH] |Structure-Activity Relationship [MESH]The mitochondrial Ca2+ uniporter: regulation by auxiliary subunits and(epmc).pdf DeepDyve Pubget Overpricing