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10.1016/j.cell.2016.06.010 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.06.010 C4967043!4967043!27374333     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2016 ; 166 (3): 651-63 Nephropedia Template TP {{tp|p=27374333|t=2016. Compositional Control of Phase-Separated Cellular Bodies |pdf=|usr=}}{{27374333}} gab.com Text Compositional Control of Phase-Separated Cellular Bodies JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=27374333 #FOAvip Cellular bodies such as P bodies and PML nuclear bodies (PML NBs) appear to be phase-separated liquids organized by multivalent interactions among proteins and RNA molecules. Although many components of various cellular bodies are known, general principles that define body composition are lacking. We modeled cellular bodies using several engineered multivalent proteins and RNA. In vitro and in cells, these scaffold molecules form phase-separated liquids that concentrate low valency client proteins. Clients partition differently depending on the ratio of scaffolds, with a sharp switch across the phase diagram diagonal. Composition can switch rapidly through changes in scaffold concentration or valency. Natural PML NBs and P bodies show analogous partitioning behavior, suggesting how their compositions could be controlled by levels of PML SUMOylation or cellular mRNA concentration, respectively. The data suggest a conceptual framework for considering the composition and control thereof of cellular bodies assembled through heterotypic multivalent interactions. Twit Text FOAVip Compositional Control of Phase-Separated Cellular Bodies ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=27374333 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27374333 #FOAvip English Wikipedia <ref>{{Cite pmid|27374333}}</ref> Compositional Control of Phase-Separated Cellular Bodies #MMPMID27374333 Banani SF; Rice AM; Peeples WB; Lin Y; Jain S; Parker R; Rosen MK Cell 2016[Jul]; 166 (3): 651-63 PMID27374333show ga Cellular bodies such as P bodies and PML nuclear bodies (PML NBs) appear to be phase-separated liquids organized by multivalent interactions among proteins and RNA molecules. Although many components of various cellular bodies are known, general principles that define body composition are lacking. We modeled cellular bodies using several engineered multivalent proteins and RNA. In vitro and in cells, these scaffold molecules form phase-separated liquids that concentrate low valency client proteins. Clients partition differently depending on the ratio of scaffolds, with a sharp switch across the phase diagram diagonal. Composition can switch rapidly through changes in scaffold concentration or valency. Natural PML NBs and P bodies show analogous partitioning behavior, suggesting how their compositions could be controlled by levels of PML SUMOylation or cellular mRNA concentration, respectively. The data suggest a conceptual framework for considering the composition and control thereof of cellular bodies assembled through heterotypic multivalent interactions. äCompositional Control of Phase-Separated Cellular Bodies (epmc).pdf DeepDyve Pubget Overpricing